GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **226 - 250** of **261** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▼	GlyTouCan ID
Acetylcholine Neurotransmitter Release Cycle	Choline O-acetyltransferase Probable vesicular acetylcholine transporter-A Ras-related protein Rab-3 Synaptotagmin Vesicle-associated membrane protein 2	B2ZGJ1 Q08C75 Q5RGB5 Q5TZ27 Q7SZZ5	chat rab3a rab3ab si:ch211-255d18.4 slc18a3a syt1 syt1a vamp2 wu:fj41c01 wu:fj61c06 wu:fk56d05 zgc:112516 zgc:73302 zgc:92899	Danio rerio (zebrafish)
FRS-mediated FGFR3 signaling	FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 8 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Putative fibroblast growth factor 1 Son of sevenless homolog	A2RRV5 B3DGE3 E7F020 O57341 P79737 Q2HXK8 Q38PL0 Q503B6 Q5MK87 Q5RKN6 Q5TKR8 Q5TLE2 Q6PBT8 Q6PC73 Q6SJP8 Q9DFC9 Q9I8X3	dob fb18e12 fc89b01 fgf-1 fgf-8 fgf1 fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf23 fgf4 fgf5 fgf8 fgf8a fgfr3 fj59e07 frs3 grb2 grb2a grb2b hrasb hrasl id:ibd5158 nras sos1 wu:fb05c08 wu:fb18e12 wu:fb34e06 wu:fc89b01 wu:fj59e07 zgc:103549 zgc:110734 zgc:158274 zgc:73077	Danio rerio (zebrafish)
EPH-Ephrin signaling	Ephrin B3 Ephrin type-A receptor 3 Ephrin type-A receptor 4a (Fragment) Ephrin type-B receptor 4a Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A5b Ephrin-B1 Ephrin-B2b receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	O13146 O13148 O73875 O93431 P79727 P79728 Q5VSJ4 Q6NZS1 Q90YC5 Q90Z31 Q90Z32 Q90Z33 Q90ZN9	D160 EphA3 RTK2 al1 efna1 efna1b efna2 efna3 efna3b efna5 efna5b efnb1 efnb2b efnb3 efnb3b ek1 ek2 epha2 epha2a epha3 epha4 epha4a epha4b epha7 ephb4a ephrin-A3 eplg6 eplg7 fc10d03 fc51g03 hm:zeh0344 id:ibd2782 id:ibd5049 id:ibd5152 lerk6 lerk7 rtk2 rtk5 rtk6 si:dkey-23k6.1 wu:fc10d03 wu:fc51g03 zeh0344 zek1 zek2 zgc:100772 zgc:111938	Danio rerio (zebrafish)
Glycosphingolipid catabolism	Cytosolic beta-glucosidase Neutral ceramidase Non-lysosomal glucosylceramidase Sphingomyelin phosphodiesterase 4 exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0JMM3 A7TUD6 B1B5D9 E7F5W0 F1QUD7 Q4V9A4 Q502A1 Q503Z4 Q5W7F1 Q6PFJ7	NSMase asah2 gba2 gba3 im:6912336 im:6912508 nSMase2 neu3.2 neu3.3 neu3.5 neu4 neuc.1 sb:eu489 si:ch73-316n6.2 si:dkey-11j5.6 smpd2 smpd2a smpd3 smpd4 zgc:100806 zgc:109998 zgc:153998	Danio rerio (zebrafish)	G58161NS
FGFR1c ligand binding and activation	Anosmin 1b Anosmin-1 Fgf23 Fibroblast growth factor 17 Fibroblast growth factor 8 Fibroblast growth factor receptor 1-A Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GAIP c-terminus interacting protein 1 Putative fibroblast growth factor 1 Transforming growth factor beta receptor III	A0A0H3UK16 B3DGE3 O57341 Q1MT36 Q38PL0 Q5MK87 Q5TLE1 Q5TLE2 Q6B337 Q6PBT8 Q6SJP8 Q90Z00 Q9DFC9 Q9IAR4	GIPC TIP-2 anos1a anos1b anosmin-1a anosmin-1b dob fc89b01 fgf-1 fgf-8 fgf1 fgf17 fgf17b fgf2 fgf20a fgf23 fgf4 fgf5 fgf6b fgf8 fgf8a fgfr1 fgfr1a gipc1 id:ibd5158 kal1.1 kal1.2 kal1a kal1b rgs19ip1 si:ch73-18k18.1 tgfbr3 wu:fb05c08 wu:fc89b01 wu:fl91z45 zgc:194535	Danio rerio (zebrafish)
Lysosomal oligosaccharide catabolism	Beta-mannosidase	Q7ZVY7	manba zgc:55493 zgc:76896	Danio rerio (zebrafish)	G70323CJ G90333CG
Sema4D induced cell migration and growth-cone collapse	PDZ-RhoGEF Plexin b1b Ras-like protein Rnd1a Receptor protein-tyrosine kinase Rho-associated protein kinase Rho-related GTP-binding protein RhoA-C	F1Q7U0 Q49U75 Q52WX7 Q5EBY4 Q7T2E8 Q90Y37	arhgef11 erbb2 plxnb1b rhoac rnd1a rnd1b rnd1l rock2 rock2a rok2 wu:fk50c04 wu:fv70f10 zgc:153089 zgc:63601	Danio rerio (zebrafish)
CS/DS degradation	Biglycan Brevican core protein Decorin Hyaluronidase Iduronate 2-sulfatase precursor Neurocan b Versican core protein	A1A5V0 A4JYN2 F1QEZ8 Q29RC1 Q6GMI5 Q75ZI3 Q803T1	DC bcan bgn bgna cspg2b dcan dcn decorin fb99b07 fi32a12 hyal1 ids ncanb vcanb wu:fb99b07 wu:fi32a12 zgc:158245 zgc:91989	Danio rerio (zebrafish)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Androgen receptor Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Nuclear receptor coactivator 2 Uncharacterized protein LOC100126107 [histone H3]-trimethyl-L-lysine(9) demethylase protein kinase C	A2RRT0 A3KPR4 A4GT83 A4QNX9 A7E2M8 A7MCA8 B3DJF8 Q0Z946 Q4QRF4 Q5BJA5 Q5XJK2 Q6PC60 Q6PI20 Q71PD7 Q7ZTT0 Q98TW1 R4GE15	LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 NR3C4 ar grip1 h2af1al h2afvb h2afvl h2afx1 h2afza h2av h2ax1 h2az2a h2az2b h3-5 h3f3a h3f3b.1 h3f3c h3f3d hist1h4l hist2h2l im:6896397 jmjd2c kdm4c ncoa2 pkn1b si:ch211-113a14.17 si:ch211-113a14.22 si:ch211-113a14.29 si:ch211-113a14.6 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 src2 tif2 wu:fd55d07 zgc:112234 zgc:113984 zgc:165555 zgc:173585 zgc:173587 zgc:194998 zgc:56685	Danio rerio (zebrafish)
Serine biosynthesis	Phosphoserine aminotransferase Phosphoserine phosphatase Serine incorporator 1 Serine incorporator 5	Q498V7 Q7SZW7 Q803I7 Q803X0	fi15b02 psat1 psph serinc1 serinc5 tde2 wu:fd02g01 wu:fd02g07 wu:fi15b02 zgc:112414 zgc:55738 zgc:77597 zgc:77622	Danio rerio (zebrafish)
Termination of O-glycan biosynthesis	Alpha-2,6-sialyltransferase Alpha-2,6-sialyltransferase CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform 1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 Protein HEG beta-galactoside alpha-2,3-sialyltransferase	A2RUW6 B8K0C9 F1R1A7 Q5NDG1 Q6R8J2 Q704S4	heg im:7151092 siat4 siat4c siat7D siat7c st3gal1l st3gal2l st3gal4 st3gal8 st6GalNAc III st6GalNAc-III st6galnac3 st6galnac4 wu:fb67c12 zgc:111788 zgc:153237 zgc:158162 zgc:73301	Danio rerio (zebrafish)
Formation of the active cofactor, UDP-glucuronate	UDP-glucose 6-dehydrogenase UDP-glucuronic acid decarboxylase 1 UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter	A8WGP7 Q6DRD7 Q6GMI9	ik:tdsubc_2a8 sb:eu659 slc35d1 slc35d1a tdsubc_2a8 ugdh uxs1 xx:tdsubc_2a8	Danio rerio (zebrafish)
Signaling by SCF-KIT	GRB2 related adaptor protein a GRB2-related adaptor protein 2 GTPase HRas GTPase NRas Grb10 protein Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Kit ligand Mast/stem cell growth factor receptor kita Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphoinositide-3-kinase, regulatory subunit 3A (gamma) Proto-oncogene tyrosine-protein kinase Src Receptor-type tyrosine-protein phosphatase U Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Son of sevenless homolog Tyrosine-protein kinase fynb Tyrosine-protein kinase yes Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0R4IUJ2 A1A5H8 A2RRV5 A9ULT3 B0S6V7 B3DGV1 B3DHG9 B3DK56 C0RW38 F1QAD7 F1RDG9 O93598 P79737 Q1JPZ3 Q1RLY5 Q503B6 Q503S8 Q567F1 Q56JH6 Q5RKN6 Q68EG5 Q68SP2 Q68SP3 Q6PC73 Q7T317 Q8JFR5	JAK2bCA Stat5 ZFMMP-9 fb18e12 fj05a08 fj21h04 fj59e07 fynb grap grap2a grapa grb10 grb10a grb2 grb2a grb2b hrasb hrasl jak2 jak2b kit kita kitla kitlga lck mmp9 nras pik3ca pik3r1 pik3r2 pik3r3a ptpru rptppsi sb:eu508 sb:eu615 sos1 sparse src stat1 stat1a stat5 stat5.1 stat5.2 stat5a stat5b stat6 stat7 tec wu:fb02g06 wu:fb07b05 wu:fb16a12 wu:fb18e12 wu:fb34e06 wu:fb65b05 wu:fi98c09 wu:fj05a08 wu:fj21h04 wu:fj59e07 wu:fj66g07 wu:fk56b03 yes yes1 zgc:103549 zgc:110202 zgc:110734 zgc:112091 zgc:136695 zgc:158274 zgc:64165 zgc:73077 zgc:73230 zgc:91987	Danio rerio (zebrafish)
Effects of PIP2 hydrolysis	Protein kinase C delta type Protein kinase C Protein kinase C Short transient receptor potential channel 3 Short transient receptor potential channel 6 isoform X1	B1H1I7 B8A467 F1RCY2 Q7ZUC5 U3N9R0	bZ1P14.9 fb09d10 fv43b11 prkcd prkcda prkceb prkcha si:rp71-1p14.9 trpc6 trpc6a trpc7b wu:fb09d10 wu:fv43b11 zgc:172124 zgc:56558	Danio rerio (zebrafish)
Methylation	Adenosylhomocysteinase Arsenite methyltransferase Catechol O-methyltransferase A Cytochrome P450 1A Glutathione S-transferase omega HemK methyltransferase family member 2 Methionine adenosyltransferase 2 subunit beta Multifunctional methyltransferase subunit TRM112-like protein Nicotinamide N-methyltransferase Probable thiopurine S-methyltransferase S-adenosylmethionine synthase S-adenosylmethionine synthase thiopurine S-methyltransferase	F1QUL7 F1QYU7 F4ZGF2 Q29R95 Q503F3 Q504A5 Q5BJJ6 Q5XJQ2 Q6DGP3 Q6DHK5 Q7ZW04 Q803T5 Q8UW07	AHCY CYP1A D150 MAT2AA ahcy as3mt cb1079 comta cyp1A1 cyp1a cyp1a1 ducttrip fd12a12 fd58h04 gsto1 hm:zeh1173 hm:zeh1364 mat1a mat2a mat2aa mat2b n6amt1 si:ch73-340n8.1 si:ch73-345a19.3 tpmt tpmt.2 trmt112 wu:fb63b04 wu:fb95e01 wu:fd12a12 wu:fd58h04 wu:fi35e01 wu:fj67b02 zfCYP1A zgc:109747 zgc:110652 zgc:136933 zgc:55442 zgc:64002 zgc:92254 zgc:92834	Danio rerio (zebrafish)
GDP-fucose biosynthesis	Fucose mutarotase GDP-L-fucose synthase	Q5SPD5 Q7ZZ03	fuom gfus gfus.1 si:dkey-235d18none tsta3 zgc:101805	Danio rerio (zebrafish)	G85196CF G96881BQ
VEGFR2 mediated cell proliferation	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 3-phosphoinositide-dependent protein kinase 1 Protein kinase C beta type Protein kinase C delta type Proto-oncogene tyrosine-protein kinase Src Vascular endothelial growth factor A-A Vascular endothelial growth factor receptor 2	O73682 Q1JPZ3 Q5GIT4 Q6NZV1 Q7SY24 Q7ZUC5 Q804J6	fb09d10 fj46f04 flk1b fv43b11 kdr kdrb pdpk1b plcg1 prkcb1 prkcbb prkcd prkcda src vegf vegfa vegfaa wu:fb09d10 wu:fj46f04 wu:fj57a05 wu:fv43b11 zgc:56558 zgc:77318	Danio rerio (zebrafish)
Sema4D mediated inhibition of cell attachment and migration	Hepatocyte growth factor receptor Plexin b1b RAS-related Ras-like protein Rnd1a Rho GTPase-activating protein 35 Rho-related GTP-binding protein RhoA-C	E7F8G5 F1Q7U0 F1QLR7 Q4V9D8 Q52WX7 Q7T2E8	LOC100004299 arhgap35a c-met cmet fb23a02 met plxnb1b rhoac rnd1a rnd1b rnd1l rras wu:fb23a02 wu:fj98h09 wu:fk50c04 zgc:153089 zgc:92588	Danio rerio (zebrafish)
Glycosphingolipid biosynthesis	2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor Beta-1,4 N-acetylgalactosaminyltransferase Beta-1,4-galactosyltransferase 5 Beta-1,4-galactosyltransferase Galactose-3-O-sulfotransferase 1a Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A Lactosylceramide alpha-2,3-sialyltransferase ceramide glucosyltransferase	A0JMC3 A1L229 A2BGH3 Q1ECX6 Q3YL68 Q501W7 Q7T3S5 Q802Y5	B4GALNT1 b3gnt5 b3gnt5a b4galnt1a b4galt5 b4galt6 cb539 gal3st1 gal3st1a sb:cb539 si:dkey-189j19.2 si:dkeyp-86g2.2 st3Gal-V st3gal5 ugcg ugt8 wu:fc08a12 zgc:112506 zgc:158609 zgc:55730	Danio rerio (zebrafish)
HDACs deacetylate histones	Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H3.2 Histone H4 Histone deacetylase 8 Polyamine deacetylase HDAC10 Uncharacterized protein LOC100126107	A3KPR4 A7E2M8 A7MCA8 B3DJF8 F1QCV2 Q4QRF4 Q5BJA5 Q5XJK2 Q6PC60 Q7SXM0 Q7ZTT0 R4GE15	LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 h2af1al h2afx1 h2ax1 hdac10 hdac8 hist1h4l hist2h2l si:ch211-113a14.17 si:ch211-113a14.22 si:ch211-113a14.29 si:ch211-113a14.6 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 zgc:112234 zgc:113984 zgc:165555 zgc:173585 zgc:173587 zgc:194998 zgc:56685	Danio rerio (zebrafish)
VEGF ligand-receptor interactions	C-fos induced growth factor Vascular endothelial growth factor A-A Vascular endothelial growth factor C	O73682 Q208T6 Q7T3I6	figf vegf vegf-d vegfa vegfaa vegfc vegfd	Danio rerio (zebrafish)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Cytosolic endo-beta-N-acetylglucosaminidase E3 ubiquitin-protein ligase AMFR Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Proteasome (Prosome, macropain) 26S subunit, ATPase, 1a Proteasome (Prosome, macropain) 26S subunit, ATPase, 1b Transitional endoplasmic reticulum ATPase UBX domain-containing protein 1 UV excision repair protein RAD23 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A1L251 F1QB30 Q32PS7 Q3B7P7 Q503I8 Q6IQ72 Q6NXA9 Q7SXA3 Q7ZU99 Q7ZWD1	amfra cdc48 engase hm:zeh0386 ik:tdsubc_1f2 ngly1 psmc1 psmc1a psmc1b rad23ab rps27a saks1 tdsubc_1f2 uba52 ubxn1 vcp wu:fa91f08 wu:fb05d04 wu:fj14c10 xx:tdsubc_1f2 zgc:123344 zgc:56516 zgc:66168 zgc:86923	Danio rerio (zebrafish)	G03934XO G25577BM G28233ME G51034LA G86419OL
EPHB-mediated forward signaling	Actin, cytoplasmic 1 Actin, cytoplasmic 2 Actin-related protein 2-A Actin-related protein 2-B Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2/3 complex subunit Actin-related protein 3 Arp2/3 complex 34 kDa subunit Cell division control protein 42 homolog GTPase HRas Neural Wiskott-Aldrich syndrome protein RAS p21 protein activator (GTPase-activating protein) 1b Rho-associated protein kinase Rho-related GTP-binding protein RhoA-C Syndecan	A2RUY4 E7F372 Q503B6 Q52WY2 Q56A35 Q66I66 Q6NZZ2 Q6P2T5 Q6PUQ3 Q6ZM62 Q7SXW6 Q7T2E8 Q7T372 Q7ZUQ0 Q7ZVF9 Q7ZVI7 Q7ZWH4 Q90Y37	ARPC1A actba actbb actr2 actr2a actr2b actr3 arp2a arp2b arpc1a arpc1b arpc2 arpc3 arpc4 arpc4l arpc5b bact bactin1 bactin2 bactzf cb440 cb871 cdc42 cdc42a fa07b12 fj15h02 fj62g06 fk84a07 hrasb hrasl rasa1b rhoac rock2 rock2a rok2 sdc2 wasla wu:fa07b12 wu:fa22f07 wu:fb07d08 wu:fb63b05 wu:fj08e12 wu:fj15h02 wu:fj62g06 wu:fk84a07 wu:fk93e03 zgc:101093 zgc:103676 zgc:110734 zgc:158395 zgc:63918 zgc:64056 zgc:77769 zgc:77932 zgc:86828	Danio rerio (zebrafish)
Tie2 Signaling	Angiopoietin-1 receptor Angiopoietin-1 Angiopoietin-2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Son of sevenless homolog phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A2RRV5 B0S6V7 B3DHG9 E7F251 F1QAD7 I6Z0F9 O73791 P79737 Q503B6 Q5RKN6 Q6PC73 Q90Z19	ang1 ang2-1 angpt1 angpt2a fb18e12 fj59e07 grb2 grb2a grb2b hrasb hrasl nras pik3ca pik3cb pik3r1 pik3r2 sos1 tek tie-2 tie2 wu:fb18e12 wu:fb34e06 wu:fb65b05 wu:fc76g06 wu:fj59e07 zgc:103549 zgc:110734 zgc:158274 zgc:73077	Danio rerio (zebrafish)
Miscellaneous transport and binding events	Cystinosin precursor Leucine rich repeat containing 8 family, member A Leucine rich repeat containing 8 family, member D Leucine-rich repeat-containing 8 VRAC subunit Ab Magnesium transporter NIPA1 Magnesium transporter protein 1 NIPA-like domain containing 3 Progressive ankylosis protein homolog B Si	A2BF98 E7FB32 P58368 Q08BM6 Q4V8W3 Q503T0 Q5XJN7 Q6DHM4 Q7ZV50	ankh ankhb ctns lrrc8a lrrc8aa lrrc8ab lrrc8d lrrc8db magt1 nipa1 nipal3 npal3 si:zfos-323e3.4 wu:fb18g12 wu:fc12a05 wu:fi21b10 zgc:101743 zgc:110194 zgc:153223 zgc:92224	Danio rerio (zebrafish)

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