GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **128** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
cGMP effects	3',5'-cyclic-AMP phosphodiesterase 4 3',5'-cyclic-nucleotide phosphodiesterase regA cGMP-specific 3',5'-cGMP phosphodiesterase 3	B0G0Y8 Q23917 Q86H13	Pde4 pde2 pde3 regA	Dictyostelium discoideum
alpha-linolenic acid (ALA) metabolism	ABC transporter D family member 3 Carrier domain-containing protein Elongation of fatty acids protein Elongation of fatty acids protein Elongation of fatty acids protein Fatty acid elongase A Fatty acid elongase sre1 Fatty acyl-CoA synthetase A Fatty acyl-CoA synthetase B Peroxisomal acyl-coenzyme A oxidase 1 Probable enoyl-CoA hydratase 2 Putative fatty acid elongase DDB_G0272012 Putative fatty acid elongase DDB_G0274669 acetyl-CoA C-acyltransferase	C7FZW5 Q1ZXQ4 Q54CJ4 Q54GQ6 Q54JK0 Q54TC9 Q54W20 Q54XZ0 Q555E8 Q55BY4 Q55DR6 Q7KWQ5 Q86IY4 Q86JM5	DDB_G0270312 DDB_G0271066 DDB_G0272012 DDB_G0274339 DDB_G0274669 DDB_G0277569 DDB_G0288001 abcD3 acox1 eloA fcsA fcsB mfe2 mfeB sre1	Dictyostelium discoideum
Zinc influx into cells by the SLC39 gene family	Protein zntA Protein zntD	Q55EA1 Q55FL1	zntA zntD	Dictyostelium discoideum
Transport of bile salts and organic acids, metal ions and amine compounds	CTL-like protein DDB_G0288717 Choline transporter-like protein 2 Multi antimicrobial extrusion family protein Multi antimicrobial extrusion family protein Urea transporter	Q54DM2 Q54I48 Q54IJ2 Q54YM8 Q86AP4	DDB_G0277263 DDB_G0278161 DDB_G0288717 DDB_G0292132 ctl2 slc44a2	Dictyostelium discoideum
Toll Like Receptor 4 (TLR4) Cascade	UPF0522 protein A UPF0522 protein B UPF0522 protein C	Q54JE7 Q54JE8 Q55BA2	DDB_G0271242 DDB_G0288095 DDB_G0288097	Dictyostelium discoideum
Thyroxine biosynthesis	Peroxinectin A Superoxide-generating NADPH oxidase heavy chain subunit A Superoxide-generating NADPH oxidase heavy chain subunit B Superoxide-generating NADPH oxidase heavy chain subunit C	Q54F44 Q6TMK4 Q86GL4 Q9XYS3	noxA noxB noxC poxA	Dictyostelium discoideum
TP53 Regulates Metabolic Genes	14-3-3-like protein 5'-AMP-activated protein kinase subunit gamma 5'-AMP-activated serine/threonine-protein kinase catalytic subunit alpha Association with the SNF1 complex (ASC) domain-containing protein GTP-binding protein Rheb homolog Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate isomerase Glutathione reductase Peroxiredoxin-4 Probable serine/threonine-protein kinase DDB_G0288795 Probable serine/threonine-protein kinase MARK-B Protein LST8 homolog Protein raptor homolog Putative thioredoxin-4 RAC family serine/threonine-protein kinase homolog Ragulator complex protein LAMTOR3 homolog Ragulator complex protein LAMTOR4 homolog Ragulator complex protein LAMTOR5 homolog RapGAP/RanGAP domain-containing protein Ras-related GTP-binding protein A Ras-related GTP-binding protein Roadblock/LAMTOR2 domain-containing protein Serine/threonine-protein kinase tor Sestrin homolog Thioredoxin domain-containing protein Thioredoxin-3 Uncharacterized protein DDB_G0292160	P29447 P54632 P54644 Q1ZXA8 Q1ZXE0 Q54D08 Q54DY3 Q54F59 Q54IF2 Q54IK1 Q54MV2 Q54N76 Q54PK6 Q54QW5 Q54UG7 Q54VB2 Q54WU6 Q54YF2 Q550Q4 Q555L5 Q557D2 Q55BR7 Q5V9E9 Q86C65 Q86J23 Q8T137 Q8T277	DDB_G0274833 DDB_G0279427 DDB_G0280527 DDB_G0283567 DDB_G0288795 DDB_G0291948 DDB_G0292160 akt ampka dagA fttB g6pd-1 g6pd-2 g6pi gpi gsr lst8 mapbpip mrkB pgi pkbA prdx4 prdx5 prkaa prkab prkag ragA ragC raptor rheb snfA tor trx3 trx4 trxC trxD zwf	Dictyostelium discoideum
Synthesis of very long-chain fatty acyl-CoAs	AMP-dependent synthetase/ligase domain-containing protein Acyl-CoA synthetase family member 3, mitochondrial Carrier domain-containing protein Elongation of fatty acids protein Elongation of fatty acids protein Elongation of fatty acids protein Fatty acid elongase A Fatty acid elongase sre1 Fatty acyl-CoA synthetase A Fatty acyl-CoA synthetase B Putative fatty acid elongase DDB_G0272012 Putative fatty acid elongase DDB_G0274669 Uncharacterized protein Very-long-chain enoyl-CoA reductase very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase	C7FZW5 Q1ZXQ4 Q54CJ4 Q54HD3 Q54JK0 Q54TC9 Q54Y54 Q54YR9 Q555E8 Q55BY4 Q55C17 Q55CD5 Q55DR6 Q7KWQ5 Q869Y3 Q86JM5	DDB_G0270106 DDB_G0270312 DDB_G0271066 DDB_G0272012 DDB_G0274669 DDB_G0275049 DDB_G0277569 DDB_G0278113 DDB_G0278683 DDB_G0288001 DDB_G0289539 eloA fcsA fcsB gpsn2 sre1	Dictyostelium discoideum
Synthesis of glycosylphosphatidylinositol (GPI)	GPI ethanolamine phosphate transferase 1 GPI mannosyltransferase 1 GPI mannosyltransferase 2 Mannosyltransferase Mannosyltransferase Phosphatidylinositol glycan, class F Phosphatidylinositol glycan, class X Phosphatidylinositol-glycan biosynthesis class W protein Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Transmembrane protein	Q1ZXB4 Q54C64 Q54IA4 Q54MC0 Q54PB0 Q54PM5 Q54QP2 Q54UQ5 Q54WY9 Q551Y7	DDB_G0276251 DDB_G0280891 pigB pigF pigN pigX pigl pigm pigw smp3	Dictyostelium discoideum
Synthesis of dolichyl-phosphate-glucose	Dolichyl-phosphate beta-glucosyltransferase	Q54J42	alg5 dgtA	Dictyostelium discoideum
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	ABC transporter B family member 2 ABC transporter B family member 3 ABC transporter B family member 6 ABC transporter B family member 7 Aldose reductase A Aldose reductase B Aldose reductase C NADP-dependent oxidoreductase domain-containing protein Peroxisomal acyl-coenzyme A oxidase 1 Probable enoyl-CoA hydratase 2 Serine protease/ABC transporter B family protein tagA Serine protease/ABC transporter B family protein tagB Serine protease/ABC transporter B family protein tagC Serine protease/ABC transporter B family protein tagD	P54683 Q23868 Q54BT3 Q54GQ6 Q54NZ7 Q54RU1 Q54XZ0 Q55DA7 Q55FL2 Q55FL3 Q6IMN8 Q8T9W1 Q8T9W4 Q9GTN7	DDB_G0268562 abcB2 abcB3 abcB6 abcB7 acox1 alrA alrB alrC mfe2 mfeB tagA tagB tagC tagD	Dictyostelium discoideum
Synthesis of bile acids and bile salts	Oxysterol-binding protein 11 Oxysterol-binding protein 4 Oxysterol-binding protein 6 Oxysterol-binding protein 8 Putative methylsterol monooxygenase DDB_G0269788 Putative methylsterol monooxygenase DDB_G0270946 Sterol desaturase family protein	Q54ID7 Q54QP6 Q54WK0 Q55D52 Q55D54 Q86HV4 Q86KG4	DDB_G0269788 DDB_G0270946 DDB_G0279611 osbD osbF osbH osbK	Dictyostelium discoideum
Synthesis of PC	Abhydrolase domain-containing protein CTL-like protein DDB_G0288717 Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Choline transporter-like protein 2 Crystal protein Major facilitator superfamily (MFS) profile domain-containing protein Phosphatidylethanolamine N-methyltransferase A Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 1 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 2 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 3 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 4 cAMP-regulated D2 protein choline-phosphate cytidylyltransferase phosphatidate phosphatase	P18142 P21837 Q54ET7 Q54GD2 Q54H38 Q54I48 Q54IJ2 Q54N21 Q54SD5 Q54SX3 Q54WD8 Q54XM0 Q550W1 Q55AQ3 Q75JA1 Q86L18 Q8T2Q6	D2 DDB_G0271730 DDB_G0276969 DDB_G0279717 DDB_G0282159 DDB_G0285555 DDB_G0288717 DDB_G0290229 DDB_G0291344 DG1056 abhd captA captB captC captD cryS ctl2 lipB pemtA slc44a2	Dictyostelium discoideum
Synthesis of PA	Counting factor 60 DDHD domain-containing protein DDHD domain-containing protein DDHD domain-containing protein DDHD domain-containing protein Mitochondrial cardiolipin hydrolase Phospholipase D A Phospholipase D B Phospholipase D C Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Probable acid phosphatase DDB_G0284753 Probable acid phosphatase DDB_G0284755 Probable glycerol-3-phosphate dehydrogenase, mitochondrial phospholipase D	Q54EA5 Q54EU4 Q54IT8 Q54P71 Q54P72 Q54PR9 Q54Q49 Q54QC1 Q54TK6 Q54UK0 Q54WR4 Q54Z25 Q554U0 Q55CZ2 Q55DN9 Q55DP0 Q86KP6	DDB_G0269584 DDB_G0269848 DDB_G0270566 DDB_G0274969 DDB_G0276935 DDB_G0281695 DDB_G0283951 DDB_G0284155 DDB_G0284753 DDB_G0284755 DDB_G0288523 DDB_G0291332 DDB_G0291694 cf60 pld1 pldA pldB pldC	Dictyostelium discoideum
Synthesis of IP3 and IP4 in the cytosol	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase Calmodulin-like protein Calmodulin Inositol 5-phosphatase 4 Inositol 5-phosphatase Inositol-tetrakisphosphate 1-kinase Kinase LIM-domain containing phosphatase Myosin-ID light chain Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN Phospholipase D Y Phospholipase D Z Uncharacterized protein phosphoinositide 5-phosphatase	O00897 P02599 Q02158 Q54CH3 Q54D97 Q54JL7 Q54K50 Q54MG8 Q54SA1 Q54TI0 Q54W40 Q553B4 Q55D87 Q7Z2B8 Q8I7P3 Q8T9S7	DDB_G0275865 DDB_G0281737 DDB_G0285967 DDB_G0292920 Dd5P1 Dd5P3 Dd5P4 ITPK1 calA calB camA cnrN mlcD pipA plc pld3 pldY pldZ pteN ptenA	Dictyostelium discoideum
Switching of origins to a post-replicative state	DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM7 DNA replication licensing factor mcm5 DNA replication licensing factor mcm6	Q54CP4 Q54LI2 Q54RU0 Q54VI9 Q86B14 Q86IF1	MCM7 mcm2 mcm3 mcm4 mcm5 mcm6 mcm7	Dictyostelium discoideum
Surfactant metabolism	ABC transporter A family member 2 ABC transporter A family member 3 ABC transporter A family member 4 ABC transporter A family member 5 ABC transporter A family member 6 Adenosine deaminase 2 Cathepsin D Saposin A Saposin B domain-containing protein	O76856 Q54BT5 Q54PT7 Q54Q68 Q553U5 Q555Z5 Q8T6J1 Q8T6J2 Q8T6J5	ADA2 CatD DDB_G0284339 abcA2 abcA3 abcA4 abcA5 abcA6 ctsD sapA	Dictyostelium discoideum
Sphingolipid catabolism	Aldehyde dehydrogenase family 3 comG PA-phosphatase related-family protein DDB_G0271516 PA-phosphatase related-family protein DDB_G0275547 PA-phosphatase related-family protein DDB_G0284367 Probable sphingosine-1-phosphate phosphatase Putative alkaline ceramidase dcd3A Sphingosine-1-phosphate lyase	Q54DG1 Q54PR7 Q54RV9 Q55A00 Q6TMJ1 Q86AF0 Q8MXL9	DDB_G0271516 DDB_G0275547 DDB_G0284367 comG dcd3A sglA sppA	Dictyostelium discoideum
Sensory perception of sweet, bitter, and umami (glutamate) taste	Inositol 1,4,5-trisphosphate receptor-like protein A	Q9NA13	iplA	Dictyostelium discoideum
Role of phospholipids in phagocytosis	PA-phosphatase related-family protein DDB_G0271516 PA-phosphatase related-family protein DDB_G0275547 PA-phosphatase related-family protein DDB_G0284367 Phospholipase D A Phospholipase D B Phospholipase D C Phospholipase D Y Phospholipase D Z Probable serine/threonine-protein kinase DDB_G0288795 RAC family serine/threonine-protein kinase homolog phospholipase D	P54644 Q54IF2 Q54K50 Q54PR7 Q54Q49 Q54SA1 Q54UK0 Q54WR4 Q54Z25 Q86AF0 Q8MXL9	DDB_G0271516 DDB_G0275547 DDB_G0284155 DDB_G0284367 DDB_G0288795 akt dagA pkbA pld1 pld3 pldA pldB pldC pldY pldZ	Dictyostelium discoideum
Rhesus glycoproteins mediate ammonium transport.	Rhesus-like glycoprotein A Rhesus-like glycoprotein B	Q8I0L6 Q9NIV0	rhgA rhgB	Dictyostelium discoideum
Response to elevated platelet cytosolic Ca2+	Probable serine/threonine-protein kinase DDB_G0288795 RAC family serine/threonine-protein kinase homolog	P54644 Q54IF2	DDB_G0288795 akt dagA pkbA	Dictyostelium discoideum
Regulation of necroptotic cell death	Dual specificity protein kinase splA Dual specificity protein kinase splB Dual specificity protein kinase zak2 Dual specificity protein kinase zakA Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable E3 ubiquitin-protein ligase rbrA Probable serine/threonine-protein kinase DDB_G0267514 Probable serine/threonine-protein kinase DDB_G0272254 Probable serine/threonine-protein kinase DDB_G0288147 Probable serine/threonine-protein kinase drkA Probable serine/threonine-protein kinase drkB Probable serine/threonine-protein kinase drkC Probable serine/threonine-protein kinase qkgA Probable serine/threonine-protein kinase roco11 Probable serine/threonine-protein kinase roco4 Probable serine/threonine-protein kinase roco5 Probable serine/threonine-protein kinase roco7 Probable serine/threonine-protein kinase roco8 RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase Seven transmembrane domain-containing tyrosine-protein kinase 1 UBC core domain-containing protein Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 P18160 P18161 Q1ZXD6 Q54CI0 Q54H45 Q54H46 Q54I29 Q54IL3 Q54JC7 Q54M77 Q54N73 Q54TA1 Q54XG4 Q54YU7 Q552C6 Q55A09 Q55GE6 Q55GU0 Q6T486 Q6XHA5 Q6XHB2 Q75JK0 Q8SSS9 Q8T2Q2	7tmk1 DDB_G0267514 DDB_G0272254 DDB_G0275145 DDB_G0278075 DDB_G0278981 DDB_G0288147 DDB_G0288683 DDB_G0289043 DpyK1 DpyK2 DpyK4 drkA drkB drkC pyK1 pyk2 pyk4 pykA pykB qkgA-1 qkgA-2 rbrA rk1 rk2 rk3 roco11 roco2-1 roco2-2 roco4 roco5 roco7 roco8 splA splB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116 vsk1 zak1 zak2 zakA	Dictyostelium discoideum
Regulation of insulin secretion	Calmodulin-binding protein Sugar transporter family protein	Q54CM5 Q54Z55	DDB_G0277773 symA	Dictyostelium discoideum	G58161NS
Regulation of TP53 Activity through Phosphorylation	Casein kinase II subunit alpha Casein kinase II subunit beta FACT complex subunit SPT16 FACT complex subunit SSRP1 Probable serine/threonine-protein kinase DDB_G0286481 Probable serine/threonine-protein kinase atr1 Probable serine/threonine-protein kinase dyrk2	Q02720 Q54BC9 Q54ER4 Q54G78 Q54LR6 Q54PF1 Q54S43	DDB_G0286481 atr1 casK csnk2b dyrk2 spt16 ssrp ssrp1	Dictyostelium discoideum

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