GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **326 - 350** of **360** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
TNF signaling	ADAM metallopeptidase domain 17 BAG cochaperone 4 Receptor interacting serine/threonine kinase 1 TNF receptor-associated factor Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	A0A286ZVH7 A0A287AP23 A0A287BPE4 A0A287BRT1 A0A5G2QLA4 F1RVZ4 P23563	ADAM17 BAG4 RIPK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2	Sus scrofa (pig)
TNFR1-induced NF-kappa-B signaling pathway	Baculoviral IAP repeat containing 2 IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Optineurin Putative inhibitor of apoptosis RBR-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Small ribosomal subunit protein RACK1 Spermatogenesis-associated protein 2 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 TNF receptor-associated factor TNF receptor-associated factor Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase 4 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A286ZI91 A0A286ZVH7 A0A286ZYB8 A0A287A5Q1 A0A287AQJ4 A0A287AUG2 A0A287BGB4 A0A287BPE4 A0A287BRT1 A0A481CGW8 A9QT41 B0LXP5 F1RVZ4 F1S196 F1S6A4 F1S7J3 F1S7S1 F1S8V5 F1SDG3 F1SME2 I3LH37 I3LI16 K7GLB8 O62640 P23563 P63246 Q7YS99	BIRC2 CHUK CYLD GNB2L1 IKBKB IKBKG MAP3K7 OPTN OTUD1 OTUD7B PIAP RACK1 RBCK1 RIPK1 RNF31 SPATA2 TAB1 TAB2 TAB3 TAK1b TNF TNFA TNFAIP3 TNFRSF1A TNFSF2 TRADD TRAF1 TRAF2 USP2 USP21 USP4	Sus scrofa (pig)
TNFR1-induced proapoptotic signaling	Baculoviral IAP repeat containing 2 FAS-associated death domain protein Inhibitor of nuclear factor kappa B kinase subunit epsilon Putative inhibitor of apoptosis RBR-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Spermatogenesis-associated protein 2 TANK binding kinase 1 TNF receptor-associated factor Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase 4 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A286ZI91 A0A286ZVH7 A0A286ZYB8 A0A287AL42 A0A287AQJ4 A0A287AUG2 A0A287B5E3 A0A287BGB4 A0A287BPE4 A0A287BRT1 F1RVZ4 F1S196 F1S6A4 F1S7J3 F1SDG3 I3LH37 I3LI16 M9MMN5 O62640 P23563 Q56VC2	BIRC2 CYLD FADD IKBKE MIB2 OTUD1 OTUD7B PIAP RBCK1 RIPK1 RNF31 SPATA2 TBK1 TNF TNFA TNFAIP3 TNFRSF1A TNFRSF6 TNFSF2 TRADD TRAF2 USP2 USP21 USP4	Sus scrofa (pig)
TNFR1-mediated ceramide production	Neutral sphingomyelinase activation associated factor Small ribosomal subunit protein RACK1 Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0A286ZVH7 A0A287A053 A0A287AXH1 F1RSY4 P23563 P63246	GNB2L1 NSMAF RACK1 SMPD2 SMPD3 TNF TNFA TNFRSF1A TNFSF2	Sus scrofa (pig)
TNFR2 non-canonical NF-kB pathway	26S protease regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 8 B-cell activating factor Baculoviral IAP repeat containing 2 CD40 ligand Lymphotoxin beta receptor Lymphotoxin-alpha Lymphotoxin-beta Mitogen-activated protein kinase kinase kinase 14 Proteasome 20S subunit alpha 2 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta type-7 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Putative inhibitor of apoptosis TNF receptor superfamily member 11a TNF receptor superfamily member 12A TNF receptor superfamily member 13C TNF receptor superfamily member 1B TNF receptor-associated factor TNF receptor-associated factor TNF superfamily member 11 TNF superfamily member 12 Tumor necrosis factor receptor superfamily member 5 Tumor necrosis factor Uncharacterized protein	A0A286ZLP7 A0A286ZN52 A0A286ZS34 A0A287AEH0 A0A287AJ47 A0A287APQ3 A0A287AWB6 A0A287B5Q7 A0A287BG14 A0A287BPP9 A0A287BRR7 A0A287BRV0 A0A288CG47 A0A480JRT9 A0A5G2Q934 A0A5G2QI19 A0A5G2QL81 A0A5G2QSU8 A0A5G2R6X9 A0A8W4FAU5 A0A8W4FCV1 A0A8W4FHK5 A0A8W4FNV3 A0MTC9 A1XQU1 F1RJX1 F1RKW8 F1RPQ3 F1RR25 F1RVZ4 F1RXA7 F1S9C7 F1SBA5 F1SGF1 F1SGM3 F1SMW9 F2Z5J1 F2Z5K2 F2Z5N0 I3L7R8 I3L871 I3LH37 I3LP81 K7GN73 O62640 P23563 P26445 P61291 P62197 Q2PYM7 Q64L94 Q8SQ34	BIRC2 CD40 CD40LG LMP2 LTA LTB LTBR MAP3K14 PIAP PRORP PSMA1 PSMA2 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB3 PSMB7 PSMB9 PSMC1 PSMC3 PSMC5 PSMC6 PSMD1 PSMD11 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 TNF TNFA TNFB TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF1B TNFRSF5 TNFSF1 TNFSF11 TNFSF12 TNFSF13B TNFSF2 TRAF2 TRAF3	Sus scrofa (pig)
TNFs bind their physiological receptors	B-cell activating factor CD27 CD70 molecule EDAR associated death domain Ectodysplasin A receptor Ectodysplasin A Lymphotoxin-alpha TNF receptor superfamily member 13B TNF receptor superfamily member 17 TNF receptor superfamily member 18 TNF receptor superfamily member 1B TNF receptor superfamily member 25 TNF receptor superfamily member 4 TNF receptor superfamily member 9 TNF superfamily member 11 TNF superfamily member 13 TNF superfamily member 15 TNF superfamily member 18 TNF superfamily member 4 TNF superfamily member 9 Tumor necrosis factor receptor superfamily member 11B Tumor necrosis factor receptor superfamily member 1A	A0A286ZPI2 A0A286ZQA0 A0A286ZVH7 A0A287A0L0 A0A287A7B3 A0A5K1VKG5 A0A5S6H780 A0A8W4FAC7 A0A8W4FCJ9 A0A8W4FMJ5 A0MTC9 F1RJX1 F1S746 F1SBT1 F1SU31 I3LDN7 I3LL00 I3LP81 K7GPY3 L7QHB1 P26445 Q4QTJ8	CD27 CD70 EDA EDAR EDARADD LTA TNFB TNFRSF11B TNFRSF13B TNFRSF17 TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF9 TNFSF1 TNFSF11 TNFSF13 TNFSF13B TNFSF15 TNFSF18 TNFSF4 TNFSF9	Sus scrofa (pig)
TRAF6 mediated NF-kB activation	Advanced glycosylation end-product specific receptor Amyloid-beta A4 protein Amyloid-beta precursor protein IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha NF-kappa-B essential modulator NF-kappa-B inhibitor alpha NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1 NF-kappa-B inhibitor-interacting Ras-like protein 2 Nuclear factor NF-kappa-B p100 subunit isoform X1 Nuclear factor NF-kappa-B p105 subunit Protein S100-A12 Protein S100-B RELA proto-oncogene, NF-kB subunit S100 calcium binding protein A12	A0A286ZTE6 A0A287A5Q1 A0A287AVR3 A0A5S6H0X2 A0A8W4FCZ9 A0A8W4FET6 A9QT41 F1S8V5 F2Z555 F6PVF4 I3L911 K9IW82 P79307 P80310 Q08353	A4 AD1 AGER APP CHUK IKBA IKBKB IKBKG NFKB1 NFKB2 NFKB2_tv2 NFKBIA NKIRAS1 NKIRAS2 RELA S100A12 S100B	Sus scrofa (pig)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	A0A287ABQ5 A7XUJ6 F1SA28	ECSIT MAP3K1 TRAF6	Sus scrofa (pig)
TWIK-related alkaline pH activated K+ channel (TALK)	Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17	A0A287A685 F1RVQ8	KCNK16 KCNK17	Sus scrofa (pig)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	Potassium channel subfamily K member Potassium channel subfamily K member Potassium channel subfamily K member	A0A287AWU0 F1RGV1 F1RRI8	KCNK1 KCNK6 KCNK7	Sus scrofa (pig)
Terminal pathway of complement	Clusterin Clusterin Complement C5 Complement C7 Complement C8 alpha chain Complement C8 gamma chain Complement component C6 Complement component C8 beta chain Complement component C9	A0A287AFQ4 A0A287AIM8 A0A287AT36 A0A5G2R8T9 A0A5S8KLN1 A0A8W4F8A6 F1S788 F1SMJ1 Q29549	C5 C6 C7 C8A C8B C8G C9 CLU	Sus scrofa (pig)
The NLRP3 inflammasome	Heat shock protein HSP 90-beta NACHT, LRR and PYD domains-containing protein 3 P2X purinoceptor Pannexin Thioredoxin-interacting protein Thioredoxin	A0A286ZKC5 A0A287B8K3 A0A5G2Q9S8 F1RNN5 H2EW08 Q2HY40	HSP90AB1 NLRP3 P2RX7 PANX PANX1 TXN TXNIP	Sus scrofa (pig)
The canonical retinoid cycle in rods (twilight vision)	ATP binding cassette subfamily A member 4 Cytochrome P450 family 4 subfamily V member 2 Lecithin retinol acyltransferase NADP-retinol dehydrogenase Receptor for retinol uptake STRA6 Retinol binding protein 1 Retinol binding protein 3 Retinol dehydrogenase 11 Retinol dehydrogenase 12 Retinol dehydrogenase 5 Retinol-binding protein Rhodopsin Short chain dehydrogenase/reductase family 9C member 7 Transthyretin Transthyretin Uncharacterized protein	A0A286ZUS8 A0A287B1J6 A0A287B476 A0A5G2QIE9 A0A5G2QTV7 F1RYR6 F1S539 F1SA23 F1SA24 F1SC80 F1SEL7 F1SIE2 F1SL80 F1SPK7 O18766 P50390	ABCA4 CYP4V2 LOC100626199 LRAT RBP1 RBP3 RBP4 RDH10 RDH11 RDH12 RDH5 RHO RHO1 SDR9C7 STRA6 TTR	Sus scrofa (pig)
Thyroxine biosynthesis	Dual oxidase 1 Glycoprotein hormones alpha chain Iodotyrosine deiodinase 1 NAD(P)H oxidase (H2O2-forming) NAD(P)H oxidase (H2O2-forming) Sodium iodide symporter Thyroid peroxidase Thyrotropin subunit beta	A0A287AZ10 A0A287B129 A0A287BQ51 K7GR01 P01219 P01224 Q8HZK3 Q9GJX7	CGA DUOX1 DUOX2 IYD SLC5A5 TPO TSHB	Sus scrofa (pig)
Toll Like Receptor 10 (TLR10) Cascade	Toll like receptor 10	I3LPE4	TLR10	Sus scrofa (pig)
Toll Like Receptor 4 (TLR4) Cascade	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Bactericidal permeability-increasing protein CD180 antigen Integrin beta Integrin subunit alpha M Lipopolysaccharide-binding protein Lymphocyte antigen 86 Lymphocyte antigen 96 Monocyte differentiation antigen CD14 TIR domain-containing adapter molecule 2 Toll-like receptor 4 dynamin GTPase dynamin GTPase dynamin GTPase	A0A287A869 A0A287AK86 A0A287AN09 A0A287B5Y6 A0A287B8X7 A0A287BLV6 A0A287BMU9 A0A480K9W0 A0A5G2REH3 A2SW51 A7BG67 F1S475 I3LCZ7 Q7YRL4	BPI CD14 CD180 DNM1 DNM2 DNM3 ITGAM ITGB2 LBP LY64 LY86 LY96 PLCG2 TICAM2 TLR4	Sus scrofa (pig)
Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll like receptor 7	A0A288CG39	TLR7	Sus scrofa (pig)
Toll Like Receptor 9 (TLR9) Cascade	Early endosome antigen 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Rabenosyn, RAB effector Toll-like receptor 9 non-specific serine/threonine protein kinase	A0A287AVI7 A0A287BHR8 A0A5G2RJ76 F1SAI0 Q5I2M3	EEA1 PIK3C3 PIK3R4 RBSN TLR9	Sus scrofa (pig)
Trafficking and processing of endosomal TLR	Cathepsin B Cathepsin K Cathepsin L Endoplasmin Legumain Procathepsin L Protein canopy homolog 3 Toll like receptor 7 Toll like receptor 8 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A287AFA5 A0A288CG39 A0A5G2QDA1 A0A5G2QE64 A0A8W4FL93 A1E295 A5GFQ5 F1S4J6 Q28944 Q5I2M3 Q9GLE3	CNPY3 CTSB CTSK CTSL CTSL1 HSP90B1 LGMN TLR7 TLR8 TLR9 TNRC5 UNC93B1	Sus scrofa (pig)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	DEK proto-onco Transcription factor AP-2-alpha	A0A287B9K7 A0A5G2QII0	DEK TFAP2A	Sus scrofa (pig)
Transferrin endocytosis and recycling	ATPase H+ transporting V0 subunit b ATPase H+ transporting V0 subunit e2 ATPase H+ transporting accessory protein 1 Homeostatic iron regulator Metalloreductase STEAP4 Mucolipin TRP cation channel 1 STEAP3 metalloreductase Serotransferrin Transferrin receptor 2 Transferrin receptor protein 1 Transferrin receptor protein 1 V-type proton ATPase proteolipid subunit V-type proton ATPase subunit C V-type proton ATPase subunit C V-type proton ATPase subunit E 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit H V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit V-type proton ATPase subunit Vacuolar proton pump subunit B	A0A287ABM6 A0A287AXI2 A0A287B538 A0A287BGV7 A0A288CFV5 A0A5G2QDQ1 A0A5G2QWF0 A0A5S6GXI4 A0A8W4F9X6 A0A8W4FHD6 A0A8W4FMK1 A0A8X9AEU4 F1CNZ4 F1RMX9 F1RSG6 F1RXD2 F1SAA2 I3LJN3 K9IWA3 K9J4U3 Q8HZV3 Q9TSV6	ATP6AP1 ATP6G2 ATP6V0A1 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E2 ATP6V1B1 ATP6V1C1 ATP6V1C2 ATP6V1E1 ATP6V1G2 ATP6V1H HFE MCOLN1 STEAP3 STEAP4 TCIRG1 TF TFR2 TFRC	Sus scrofa (pig)
Translocation of ZAP-70 to Immunological synapse	Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II DR-alpha MHC class II antigen MHC class II histocompatibility antigen SLA-DRB1 SLA class II histocompatibility antigen, DQ haplotype D alpha chain SLA-DQ beta1 domain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Uncharacterized protein protein-tyrosine-phosphatase	A0A286ZKB7 A0A286ZUJ9 A0A287AC24 A0A287AT33 A0A287B968 A0A287BD80 A0A287BF11 A0A287BQ31 A0A5G2QCN4 A0A8W4F9V5 A0A8W4FBN9 A0A8W4FJW4 A0A8W4FNK4 A0A8W4FP49 A0A8X9AEU9 F1S6S1 F1S975 F1SV94 I3L556 I3LAQ5 K7GS60 P15981 Q5PXD3 Q764N2 Q7YQ94 Q85ZW4	CD247 CD3D CD3E CD3G CD4 DRA HLA-DRA LCK LOC100153139 PTPN22 SLA-DQA SLA-DQA1 SLA-DQB1 SLA-DR SLA-DRA SLA-DRA1 SLA-DRB1	Sus scrofa (pig)
Transport of bile salts and organic acids, metal ions and amine compounds	Choline transporter-like protein 2 Choline transporter-like protein 4 Choline transporter-like protein Choline transporter-like protein Multidrug and toxin extrusion protein Multidrug and toxin extrusion protein Solute carrier family 10 member 6 Solute carrier family 14 member 2 Urea transporter 1	A0A287ARM7 A0A287BPI3 A0A8W4FLB7 A5PF08 F1RQG4 F1S542 F1S584 F1SDC6 I3LIG7	CTL2 CTL4 SLC10A6 SLC14A1 SLC14A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC47A1 SLC47A2 TPPT1	Sus scrofa (pig)
Transport of fatty acids	Apolipoprotein D Lipocalin 12 Lipocalin 15 Lipocalin 9 Lipocalin-1 Long-chain-fatty-acid--CoA ligase Odorant binding protein 2B long-chain-fatty-acid--CoA ligase long-chain-fatty-acid--CoA ligase	A0A287AE71 A0A287AN57 A0A287B9B7 A0A287BA72 A0A5G2QCL8 A0A5G2R0H6 A0A5K1TWC1 F1RKK0 P53715	APOD LCN1 LCN12 LCN15 LCN9 OBP2B SLC27A1 SLC27A4 SLC27A6	Sus scrofa (pig)
Transport of organic anions	Monocarboxylate transporter 8 Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member Vasopressin-neurophysin 2-copeptin	A0A286ZS46 A0A287ASP2 A0A5G2QZU2 A0A5K1U410 A0A8W4FMT0 F1SQZ5 F1SUN1 I3LJG4 P01183 Q2QEH5	AVP SLC16A2 SLCO1A2 SLCO1B2 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1	Sus scrofa (pig)

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