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MIRAGE
Signaling by SCF-KIT

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
KITLG-1sSCFKITLG-1(192-273)sSCF dimerKITKIT:sSCF dimerKIT:sSCF dimer:KITp-KIT complexATPADPPI3K alphaPI3K:p-KIT:sSCF dimer:p-KITPIP2PIP3p-VAV1:PIP3VAV1RAC1:GDPGDPGTPRAC1:GTPSrc family tyrosine kinases (SFKs)SFKs:p-KIT complexSFKs:p-8Y-KIT:sSCF dimer:p-8Y-KITGRB2-1:SOS1GRB2:SOS1:p-KIT complexSHP2SHP2:SFKs:p-KIT:sSCF dimer:p-KITp-SHP2:p-KIT complexAsh-LGRB2:p-SHP2:p-KIT complexGAB2:GRB2:p-SHP2:p-KIT complexGAB2p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexPI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexp21 RAS:GTPp21 RAS:GDPTyrosine kinases:p-KIT complexTyrosine kinasesAdapter proteins:p-KIT complexAdapter proteinsJAK2:SFKS:p-KIT complexJAK2p-JAK2:SFKs:p-KIT complexSTATsp-JAK2:SFKs:p-KIT complex:STATsp-JAK2:SFKs:p-KIT complex:p-STATsp-JAK2:SFKs:p-KIT complex:p-STAT dimersp-STAT dimersPTPRUPTPRU:KITKIT:type II TKIstype II KIT binding TKIsKIT:sSCF dimer:KIT:type I KIT binding TKIs:type I KIT binding TKIsKIT:ripretinibDCC2618
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025