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MIRAGE
EPHB-mediated forward signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CFL1p-S3-CFL1ADPATPITSN1p-EPHBs:EFNBs:ITSN1p-EPHB:EFNB oligomersp-EPHBs:EFNBs:ITSN1:N-WASPWASLp-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTPCDC42:GDPGDPGTPPIP2p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2ARP2/3 complex (ATP bound)p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actinG-actinEFNBs:p-EPHBs:KALRNKALRNRAC1:GTPRAC1:GDPGDPRAC1:GTP:PAK1 dimer:RAC1:GTPPAK1 dimerRAC1-GTP:p-S144,T423-PAK1FAKEFNBs:p-EPHBs:FAKEFNBs:p-EPHBs:p-Y397-FAKEFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28ARHGEF28RHOA:GDPRHOA:GTPROCK1,ROCK2RHOA:GTP:ROCK1,ROCK2p-LIMKLIM KinasesGlu:NMDAR:GlyEFNBs:p-EPHBs:SFKs:Glu:NMDAR:GlyEFNBs:p-EPHBs:SFKsEFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:GlyTIAM1EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1RAC1:GDPRAC1:GTPRASA1p-EPHBs:EFNBs:RASA1HRAS:GTPp-EPHBs:EFNBs:RASA1:HRAS:GTPH2OPip-EPHBs:EFNBs:RASA1:HRAS:GDPSDC2HSPGp-Y179,Y191-SDC2 cluster
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 1 - 10 of 23 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O00401 Actin nucleation-promoting factor WASL
  • WASL
 view
O15143 Actin-related protein 2/3 complex subunit 1B
  • ARC41
  • ARPC1B
 view
O15511 Actin-related protein 2/3 complex subunit 5
  • ARC16
  • ARPC5
 view
O60229 Kalirin
  • DUET
  • DUO
  • HAPIP
  • KALRN
  • TRAD
 view
O75116 Rho-associated protein kinase 2
  • KIAA0619
  • ROCK2
 view
P01112 GTPase HRas
  • HRAS
  • HRAS1
 view
P20936 Ras GTPase-activating protein 1
  • GAP
  • RASA
  • RASA1
 view
P23528 Cofilin-1
  • CFL
  • CFL1
 view
P34741 Syndecan-2
  • HSPG1
  • SDC2
 view
P53671 LIM domain kinase 2
  • LIMK2
 view
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025