PINK1-PRKN Mediated Mitophagy

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PINK1PINK1_HUMANPINK1p-S228,S402-PINK1 dimerADPATPp-S65-PRKN:Ub-MOM proteinsParkinPolyUb-MOM substrates of PRKNUb:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3OPTNTBK1:OPTN:K63-polyUb-mitochondrial proteinsK63polyUb-MOM proteinsTBK1p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteinsATG9A:p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteinsATG9APINK1Ub-MOM proteinsp-S65-Ub:MOM proteinsPRKN:Ub-MOM proteinsPRKNK48polyUb-MOM proteinsK48polyUB Mitophagy Substrates:SQSTM1p62LC3:K48polyUB Mitophagy Substrates:SQSTM1LC3ATG5:ATG12ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteinsMAP1LC3B:p-S-TBK1:p-S-OPTN:K63polyUb-mitochondrial proteinsMAP1LC3B
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025