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MIRAGE
Sensing of DNA Double Strand Breaks

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MRE11ARAD50:MRE11ARAD50IMA2NBN:KPNA2NBNIMA2NBNMRNdsDNADNA double-strand break endsDSB inducing agentsDNA DSBs:MRNATM dimer:KAT5DNA DSBs:MRN:ATM dimer:KAT5CoAAc-CoADNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5ADPp-S1981,Ac-K3016-ATMDNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5ATP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 5 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O60934 Nibrin
  • NBN
  • NBS
  • NBS1
  • P95
 view
P49959 Double-strand break repair protein MRE11
  • HNGS1
  • MRE11
  • MRE11A
 view
P52292 Importin subunit alpha-1
  • KPNA2
  • RCH1
  • SRP1
 view
Q13315 Serine-protein kinase ATM
  • ATM
 view
Q92878 DNA repair protein RAD50
  • RAD50
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025