TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
NDRG1 Genep-S15,S20-TP53 Tetramer:NDRG1 Genep-S15,S20-TP53 TetramerRTPBCLG Genep-S15,S20-TP53 Tetramer:BCL2L14 GeneBCLGp-S15,S20-TP53 Tetramer:BIRC5 GeneBIRC5 GeneBIRC5PIG3 Gene(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene(p-S15,S20-TP53,TP63,TP73):(ASPP1,ASPP2)PIG31,2-NaphthoquinonesemiquinoneH+TPNTPNHO2O2.-p-S15,S20-TP53 Tetramer:BCL6 GeneBCL6 geneBCL6PERP Gene(p-S15,S20-TP53,TP63):PERP Genep-S15,S20-TP53,TP63PERPp-S15,S20-TP53 Tetramer:RABGGTA GeneRABGGTA GeneRABGGTARGGTGGTBRGGT:CHMCHMTP53I3 Dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P04637 Cellular tumor antigen p53
  • P53
  • TP53
view
P24386 Rab proteins geranylgeranyltransferase component A 1
  • CHM
  • REP1
  • TCD
view
Q13625 Apoptosis-stimulating of p53 protein 2
  • ASPP2
  • BBP
  • TP53BP2
view
Q53FA7 Quinone oxidoreductase PIG3
  • PIG3
  • TP53I3
view
Q92597 Protein NDRG1
  • CAP43
  • DRG1
  • NDRG1
  • RTP
view
Q9BZR8 Apoptosis facilitator Bcl-2-like protein 14
  • BCL2L14
  • BCLG
view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025