Neddylation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
UCHL3,SENP8:NEDD8(1-88)NEDD8_HUMANH2OUCHL3,SENP8:NEDD8NEDD8-UBA3:NAE1:NEDD8AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8AcM-UBE2MAcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8NEDD8:UBC12NEDD8-UBA3:NAE1CRL E3 ubiquitin ligasesCRL E3 ubiquitin ligase:CAND1CAND1RBX1:CUL4:DDB1:DCAFsCRL4 E3 ubiquitin ligase:CAND1CAND1DCUN1DsNEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1DsSCF E3 ubiquitin ligase:COMMDs;CCDC22NEDD8:UBC12NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5CRL2 E3 ubiquitin ligase:COMMDs:CCDC22DCUN1D1,2,4,5DCUN1D1,2,4,5NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5NEDD8-AcM-UBE2MRBX1:CUL4:DDB1:DCAFs:COMMDs:CCDC22CUL9:RBX1NEDD8-AcM-UBE2M:CUL9:RBX1NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5NEDD8CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5hydroxyPro-HIF-alphaRBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alphaECV E3 ligase complexUbiquitinated HIF-alpha:VHL:EloB:EloC:CUL2:RBX1UbNEDD8,UBDNEDD8,UBD:NUB1:26S proteasome26S proteasomeNUB1UBXN7UBXN7:NPLOC4:UBF1:VCP hexamerNPLOC4:UBF1:VCP hexamerub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamerub-NFE2L2KEAP1:NEDD8-CUL3:RBX1NEDD8UCHL3,SENP8ATPPPiUBA3:NAE1AMPDCUN1D3 mRNADCNL3_HUMANCRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1DsRBX1:CUL3:BTB:COMMDs:CCDC22NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5CRL5 E3 ubiquitin ligase:COMMDs:CCDC22NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1DsNEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1DsAcM-UBE2Fub-BIRC5BIRC5NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1DsCRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1DsUBE2D1,2,3:UbiquitinUBE2D1,2,3ub-UBXN7KEAP1:NEDD8-CUL3:RBX1:NFE2L2NFE2L2ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1CRL E3 ubiquitin ligase:COMMDs:CCDC22COMMDs:CCDC22COMMDs:CCDC22NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5AcM-UBE2MNEDD8-CUL9:RBX1NEDD8-CUL9:RBX1:CUL7:CCDC8:OBSL13M complexRBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_000373 Q9UK22 F-box only protein 2 view
GL_001477 Q9NRD1 F-box only protein 6 view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025