Regulation of expression of SLITs and ROBOs

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SLIT2 geneSLIT2SLIT1SLIT1:COL4A5Collagen alpha-5(IV) chainsHOXA2HOXA2:ROBO2 geneROBO2 geneROBO3 geneROBO3.1 mRNAUbUb-ROBO3.1:ZSWIM8-CUL2ROBO3.1:ZSWIM8-CUL2ISL1:LHX3/4:LDB1:SLIT2 geneISL1:LHX3/4:LDB1DystroglycanSLIT2:DystroglycanROBO1 geneLHX2:ROBO1 geneLHX2ROBO1H2OPolyUb-ROBO1LHX2:ROBO2 geneROBO2LHX2,(LHX9):ROBO3 geneLHX2,(LHX9)MSI1ROBO3.1 mRNA:MSI1ROBO3.1ZSWIM8-CUL2 E3 ubiquitin ligaseROBO3.2 mRNAPABPTranslated ROBO3.2 mRNA in complex with NMD-initiating UPF2Exon Junction:UPF2:UPF3 ComplexETF180S ribosomeCap Binding Complex (CBC)tRNAeRF3:GDPP220ROBO3.2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025