Constitutive Signaling by Overexpressed ERBB2

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ERBB2:ERBIN:HSP90:CDC37HSP90ERBB2 homodimerCDC37LAP2ATPp-ERBB2 homodimerADPSHCp-ERBB2 homodimer:SHC1p-ERBB2 homodimer:p-Y349,Y350-SHC1p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1GRB2-1:SOS1GTPp21 RAS:GTPGDPp21 RAS:GDPERBB2:trastuzumab:ERBIN:HSP90:CDC37D5v8TKIs (ERBB2)ERBB2:TKIs:ERBIN:HSP90:CDC37
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 9 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P01111 GTPase NRas
  • HRAS1
  • NRAS
view
P01112 GTPase HRas
  • HRAS
  • HRAS1
view
P04626 Receptor tyrosine-protein kinase erbB-2
  • ERBB2
  • HER2
  • MLN19
  • NEU
  • NGL
view
P07900 Heat shock protein HSP 90-alpha
  • HSP90A
  • HSP90AA1
  • HSPC1
  • HSPCA
view
P29353 SHC-transforming protein 1
  • SHC
  • SHC1
  • SHCA
view
Q05209 Tyrosine-protein phosphatase non-receptor type 12
  • PTPN12
view
Q07889 Son of sevenless homolog 1
  • SOS1
view
Q16543 Hsp90 co-chaperone Cdc37
  • CDC37
  • CDC37A
view
Q96RT1 Erbin
  • ERBB2IP
  • ERBIN
  • KIAA1225
  • LAP2
view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025