FCGR3A-mediated phagocytosis

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
VAV1,2,3PIP3:VAV1,2,3PIP3Lma amastigote surfaceIgG:Lma amastigote surfaceIgGLPG1G2IgG:LPG1G2IgG:Lma antigensIgG:Lma antigens:FCGR3A:CD3 dimersFCGRIIIA:CD3G/CD3Z dimersIgG:Lma antigens:FCGR3A:p-CD3 dimersATPADPIgG:Lma antigens:FCGR3A:p-CD3 dimers:SYKSYKIgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYKIgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3GTPGDPRAC1:GTPRAC1:GDPIgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMOCRK:DOCK180:ELMO1,ELMO2WRC:IRSp53/58:RAC1:GTP:PIP3BAIAP2WRCp-Y-WRC:IRSp53/58:RAC1:GTP:PIP3p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3CDC42:GDPCDC42:GTPPIP2PI(4,5)P2:WASP/N-WASPWASP/N-WASPCDC42:GTP:WASP/N-WASPCDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsSH3 domain proteinsWIP family proteinsCDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsARP2/3 complex (ATP bound)WAVE2, WASP, N-WASP:ARP2/3 complex:G-actinWAVE2, WASP, N-WASPG-actinMother filament:branching complexF-actinMother filament:ARP2/3:actin:ADPMother filament:branching complex:daughter filamentMyosin-X dimerActin filament bound Myosin-XPiPI(3,4)P2MyosinMyosin-Actin filamentsIgG:Leishmania surface:FCGR3A
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025