Antigen processing: Ubiquitination & Proteasome degradation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Activating enzymes E1E1 bound ubiquitinATPPPiMg2+UbAMPUb:E2sE2 Ubiquitin-conjugating enzymeantigenic substrateAg-substrate:E3:E2:UbE3 ligases in proteasomal degradationE3:Ub:substrateE3:K48-polyubiquitinated substrateK48polyUb-antigenic substrateoligopeptideoligopeptideL-amino acidoligopeptide
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 110 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
A0AVT1 Ubiquitin-like modifier-activating enzyme 6
  • MOP4
  • UBA6
  • UBE1L2
view
O00231 26S proteasome non-ATPase regulatory subunit 11
  • PSMD11
view
O00487 26S proteasome non-ATPase regulatory subunit 14
  • POH1
  • PSMD14
view
O14543 Suppressor of cytokine signaling 3
  • CIS3
  • SOCS3
  • SSI3
view
O14818 Proteasome subunit alpha type-7
  • HSPC
  • PSMA7
view
O43242 26S proteasome non-ATPase regulatory subunit 3
  • PSMD3
view
O60291 E3 ubiquitin-protein ligase MGRN1
  • KIAA0544
  • MGRN1
  • RNF156
view
O60662 Kelch-like protein 41
  • KBTBD10
  • KLHL41
  • KRP1
view
O94822 E3 ubiquitin-protein ligase listerin
  • C21orf10
  • C21orf98
  • KIAA0714
  • LTN1
  • RNF160
  • ZNF294
view
O94874 E3 UFM1-protein ligase 1
  • KIAA0776
  • MAXER
  • NLBP
  • RCAD
  • UFL1
view
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_000373 Q9UK22 F-box only protein 2 view
GL_001477 Q9NRD1 F-box only protein 6 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025