Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
AntigenAntigen:BCRBCRSYKAntigen:p-BCR:SYKAntigen:p-BCRATPAntigen:p-BCR:p-SYKADPBLNK:GRB2:SOS1:CIN85Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1Vav1Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2Nck1Plcg2BTKPIP3BTK inhibitorsBTK:BTK inhibitorsGrb2CD19 Signalosomep-CD19:VAV1PIK3CD:PIK3R1p-Y139-DAPP1:PIP3Dapp1p-Y139-DAPP1:PLCG2:PIP3PIP2IP3DAGSTIM1:CalciumCa2+STIM1 DimerTrpc1STIM1:TRPC1Ca2+
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 2 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P29994 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
  • Insp3r
  • Itpr1
view
P84903 Stromal interaction molecule 1
  • Sim
  • Stim1
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025