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The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases.
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Nutrient availability regulates proline/alanine transporters in Trypanosoma brucei.
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The multidomain architecture of a bacteriophage endolysin enables intramolecular synergism and regulation of bacterial lysis.
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Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
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Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
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Structure of an ancestral ADP-dependent kinase with fructose-6P reveals key residues for binding, catalysis, and ligand-induced conformational changes.
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Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney.
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A versatile cis-prenyltransferase from Methanosarcina mazei catalyzes both C- and O-prenylations.
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The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
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Lectins engineered to favor a glycan-binding conformation have enhanced antiviral activity.
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