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The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases.
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Smurf2 exerts neuroprotective effects on cerebral ischemic injury.
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The scrambled story between hyaluronan and glioblastoma.
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The multidomain architecture of a bacteriophage endolysin enables intramolecular synergism and regulation of bacterial lysis.
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Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
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Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
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Structure of an ancestral ADP-dependent kinase with fructose-6P reveals key residues for binding, catalysis, and ligand-induced conformational changes.
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A versatile cis-prenyltransferase from Methanosarcina mazei catalyzes both C- and O-prenylations.
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The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
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Lectins engineered to favor a glycan-binding conformation have enhanced antiviral activity.
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Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22.
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Endolysosomal N-glycan processing is critical to attain the most active form of the enzyme acid alpha-glucosidase.
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Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.
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The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi.
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Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide.
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