CBM13

Summary
Family
Carbohydrate-Binding Module Family 13
CAZy
Activities
Modules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
Protein List
Displaying entries 151 - 175 of 374 in total
UniProt ID Protein Name GenBank Gene ID Enzyme Organism
Q9EWL5 Putative secreted protein
Q75VL8 Cytolysin
C9ZEC5 Putative secreted glycosyl hydrolase
A0A060ZLI9 Hydrolytic protein
Q5CZV4 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
Q9L0N4 Putative hydrolytic protein
A0A8B0E067 DUF1080 domain-containing protein
Q28CC6 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
Q08EC9 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
Q9ZBF7 Putative hydrolytic protein
Q7Z1I0 Calcium up-regulated protein F
Q8N3T1 Polypeptide N-acetylgalactosaminyltransferase 15
  • 2.4.1.41
S5S833 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
Q08CC3 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
Q6WV16 N-acetylgalactosaminyltransferase 6
  • 2.4.1.41
A0A8A1V3L3 Ricin B-type lectin domain-containing protein
A0A0M4EJ61 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
A8E4N1 AIM1L protein
L8EPN5 Carbohydrate-binding protein
B3DHD4 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
A0A7Y3Z3R9 Cytolysin
C9Z5M3 Putative secreted protein
A6QLD9 Polypeptide N-acetylgalactosaminyltransferase
  • 2.4.1.-
A0A165L8U3 Glucan endo-1,3-beta-glucosidase
  • 3.2.1.39
Q9K473 Putative secreted glycosyl hydrolase

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024