ossification of the posterior longitudinal ligament of spine

Summary
Synonym
  • OPLL
Definition
A connective tissue disease characterized by ectopic ossification of the posterior longitudinal spinal ligament resulting in spinal cord compression, myelopathy and hyperreflexia.
Super Class
connective tissue disease
Disease Ontology
DOID:0060887
Mondo Disease Ontology
OMIM
GARD
MGI genotype (from TogoID)
Related Genes
Displaying all 2 entries
Gene ID Gene Symbol Description Source
652 BMP4 bone morphogenetic protein 4
5167 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
Displaying all 2 entries
Gene ID Gene Symbol Description Source
12159 Bmp4 bone morphogenetic protein 4
18605 Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1
Displaying 1 entry
Gene ID Gene Symbol Description Source
85496 Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1
Displaying 1 entry
Gene ID Gene Symbol Description Source
33432 dpp decapentaplegic
Displaying 1 entry
Gene ID Gene Symbol Description Source Organism
399322 bmp4.S bone morphogenetic protein 4 S homeolog Xenopus laevis (African clawed frog)
Displaying all 3 entries
Gene ID Gene Symbol Description Source
179068 dbl-1 Protein dbl-1
179663 enpp-1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein
179665 C27A7.3 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3
Displaying all 2 entries
Gene ID Gene Symbol Description Source
850391 NPP1 nucleotide diphosphatase/phosphodiesterase NPP1
856699 NPP2 nucleotide diphosphatase/phosphodiesterase NPP2

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024