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Lewy body dementia
Summary
- Synonym
-
- Dementia with Lewy bodies
- Diffuse Lewy body disease
- Lewy body disease
- Senile dementia of the Lewy body type
- Definition
- A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
- Super Class
- dementia
External Links
- Disease Ontology
- DOID:12217
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- GARD
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 308 | ANXA5 | annexin A5 | |
| 348 | APOE | apolipoprotein E | |
| 1137 | CHRNA4 | cholinergic receptor nicotinic alpha 4 subunit | |
| 1139 | CHRNA7 | cholinergic receptor nicotinic alpha 7 subunit | |
| 1230 | CCR1 | C-C motif chemokine receptor 1 | |
| 2002 | ELK1 | ETS transcription factor ELK1 | |
| 2629 | GBA1 | glucosylceramidase beta 1 | |
| 2861 | GPR37 | G protein-coupled receptor 37 | |
| 3480 | IGF1R | insulin like growth factor 1 receptor | |
| 3481 | IGF2 | insulin like growth factor 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 34304 | nAChRalpha6 | nicotinic Acetylcholine Receptor alpha6 | |
| 42549 | InR | Insulin-like receptor | |
| 42919 | nAChRalpha2 | nicotinic Acetylcholine Receptor alpha2 | |
| 42920 | nAChRbeta2 | nicotinic Acetylcholine Receptor beta2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001300 | Parkinsonism |
| HP:0000726 | Dementia |
| HP:0007159 | Fluctuations in consciousness |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002367 | Visual hallucination |
| HP:0100315 | Lewy bodies |
| HP:0000746 | Delusion |
