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Insulin-like receptor
Summary
- Gene Symbol
-
- InR
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Cell membrane
- Cell projection
- Cleavage on pair of basic residues
- Developmental protein
- Differentiation
- Disulfide bond
- Glycoprotein
- Growth regulation
- Manganese
- Metal-binding
- Neurogenesis
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- SH3-binding
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| P09208 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| open tracheal system development | ||
| positive regulation of fat cell proliferation | ||
| primary spermatocyte growth | ||
| triglyceride homeostasis |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| growth cone membrane |
|
|
| plasma membrane | ||
| axon | ||
| insulin receptor complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| insulin receptor substrate binding | ||
| SH3 domain binding |
|
|
| insulin receptor activity | ||
| phosphatidylinositol 3-kinase binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- insulin receptor a
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050470 | Donohue syndrome | |
| DOID:0050696 | fetal alcohol spectrum disorder | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0050741 | alcohol dependence | |
| DOID:0050782 | Zollinger-Ellison syndrome | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:0070220 | familial hyperinsulinemic hypoglycemia 5 | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma |
