Lewy body dementia

Summary
Synonym
  • Dementia with Lewy bodies
  • Diffuse Lewy body disease
  • Lewy body disease
  • Senile dementia of the Lewy body type
Definition
A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
Super Class
dementia
External Links
Disease Ontology
DOID:12217
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 21 - 28 of 28 in total
Gene ID Gene Symbol Description Source
5648 MASP1 MBL associated serine protease 1
5743 PTGS2 prostaglandin-endoperoxide synthase 2
7412 VCAM1 vascular cell adhesion molecule 1
8398 PLA2G6 phospholipase A2 group VI
8803 SUCLA2 succinate-CoA ligase ADP-forming subunit beta
10724 OGA O-GlcNAcase
23583 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
57103 TIGAR TP53 induced glycolysis regulatory phosphatase
Displaying all 3 entries
Gene ID Gene Symbol Description Source
14466 Gba1 glucosylceramidase beta 1
16002 Igf2 insulin-like growth factor 2
18538 Pcna proliferating cell nuclear antigen
Displaying all 2 entries
Gene ID Gene Symbol Description Source
24483 Igf2 insulin-like growth factor 2
25737 Pcna proliferating cell nuclear antigen
Displaying all 4 entries
Gene ID Gene Symbol Description Source
173574 gba-1 Putative glucosylceramidase 1
177314 gba-4 Putative glucosylceramidase 4
178535 gba-3 Putative glucosylceramidase 3
183155 gba-2 Putative glucosylceramidase 2
The Human Phenotype Ontology
Displaying all 7 entries
HPO ID HPO Term
HP:0001300 Parkinsonism
HP:0000726 Dementia
HP:0007159 Fluctuations in consciousness
HP:0000006 Autosomal dominant inheritance
HP:0002367 Visual hallucination
HP:0100315 Lewy bodies
HP:0000746 Delusion
Displaying 1 entry
Gene ID Gene Symbol Description
2629 GBA1 glucosylceramidase beta 1

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Last updated: August 19, 2024