amyloidosis

Summary
Synonym
  • amyloid disease
Definition
A disease of metabolism that is characterized by extracellular tissue deposition of mis-folded amyloid fibrils built up by twisted protofilaments, deposited in the spaces between the cells of vital organs, causing disruption of organ tissue structure and function. These deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition.
Super Class
disease of metabolism
Disease Ontology
DOID:9120
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
MGI genotype (from TogoID)
Related Genes
Displaying all 4 entries
Gene ID Gene Symbol Description Source
325 APCS amyloid P component, serum
2805 GOT1 glutamic-oxaloacetic transaminase 1
5054 SERPINE1 serpin family E member 1
7276 TTR transthyretin

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025