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membrane metalloendopeptidase

Summary

Gene Symbol

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009251
PubChem: 100009251

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Myristate
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08049	Atriopeptidase Enkephalinase Neutral endopeptidase 24.11 Skin fibroblast elastase
A0A5F9D6I8	Atriopeptidase Enkephalinase Neutral endopeptidase 24.11 Skin fibroblast elastase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
kidney development
proteolysis
peptide metabolic process
substance P catabolic process
bradykinin catabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

catabolic process [inference]

hormone catabolic process

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

hormone metabolic process [inference]

hormone catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

heterocycle metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

replicative senescence

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

small molecule metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organic cyclic compound metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

heterocycle metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

replicative senescence

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

amyloid-beta clearance

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-B [inference]

cellular response to UV-B

cellular response to UV [inference]

response to UV-A [inference]

cellular response to UV-A

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

hormone catabolic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm
plasma membrane	IEA	30032202
brush border
synaptic vesicle
axon

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

neuron projection terminus

cluster of actin-based cell projections [inference]

brush border

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IEA	22301074 30032202
zinc ion binding
peptide binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endothelin-converting enzyme

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Ortholog

Displaying entries **1 - 10** of **105** in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	4311	HUMAN72976
Mus musculus	17380	MOUSE38443
Rattus norvegicus	24590	RATNO24483
Pan troglodytes	460792	PANTR32478
Canis lupus familiaris	477120	CANLF09209
Bos taurus	536741	BOVIN15121
Macaca mulatta	707667	MACMU28416
Monodelphis domestica	100012497	MONDO31430
Equus caballus	100053541	HORSE12077
Ornithorhynchus anatinus	100092983	ORNAN12711