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membrane metallo-endopeptidase

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24590

PubChem

24590

Alliance of Genome Resources

RGD:3098

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Myristate
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P07861	Atriopeptidase Enkephalinase Neutral endopeptidase 24.11 Skin fibroblast elastase
A6JVN6	Atriopeptidase Enkephalinase Neutral endopeptidase 24.11 Skin fibroblast elastase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
kidney development	ISS
kidney development	ISO
kidney development	IEP	1547865
kidney development	IEA
placenta development	IEP	1547865

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

catabolic process [inference]

hormone catabolic process

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta clearance by cellular catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta clearance by cellular catabolic process

heterocycle metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

replicative senescence

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

small molecule metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

organic cyclic compound metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

neuropeptide processing

lactam metabolic process [inference]

creatinine metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta clearance by cellular catabolic process

heterocycle metabolic process [inference]

lactam metabolic process [inference]

creatinine metabolic process

replicative senescence

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

cognition [inference]

learning or memory

behavior [inference]

learning or memory

amyloid-beta clearance

amyloid-beta clearance by cellular catabolic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-B [inference]

cellular response to UV-B

cellular response to UV [inference]

response to UV-A [inference]

cellular response to UV-A

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to estrogen

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

Displaying entries **1 - 5** of 44 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IEA
nucleoplasm	ISO
nucleoplasm	IEA
cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

cytosol

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding	ISO
phosphatidylserine binding	IEA
endopeptidase activity	ISO
metallocarboxypeptidase activity	ISO
metallocarboxypeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

phosphatidylglycerol binding [inference]

cardiolipin binding

amide binding [inference]

peptide binding

ion binding [inference]

anion binding [inference]

phosphatidylglycerol binding [inference]

cardiolipin binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Reverse transcriptase, RNase H-like domain

Functional Category

H: Coenzyme transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
X: Mobilome: prophages, transposons

Displaying **all 6** entries
Gene Ontology
amyloid-beta clearance
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:13250	diarrhea	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **114** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4311	Xenbase:XB-GENE-1011098	HUMAN72976
Drosophila melanogaster	5251	FB:FBgn0038818
Mus musculus	17380	Xenbase:XB-GENE-1011098	MOUSE38443
Drosophila melanogaster	18675	FB:FBgn0038818
Xenopus tropicalis	24590	Xenbase:XB-GENE-1011098
Drosophila melanogaster	27390	FB:FBgn0029843
Xenopus tropicalis	31547	Xenbase:XB-GENE-1011098
Xenopus tropicalis	40588	Xenbase:XB-GENE-1011098
Xenopus tropicalis	42449	Xenbase:XB-GENE-1011098
Drosophila melanogaster	79258	FB:FBgn0038818

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements