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deoxyribonuclease 1

Summary

Gene Symbol

DNASE1

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009513
PubChem: 100009513

Annotation

Keyword

Actin-binding
Apoptosis
Calcium
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Nucleus
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O18998	Deoxyribonuclease I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
apoptotic process
DNA catabolic process	IEA	22301074 30032202
regulation of neutrophil mediated cytotoxicity
neutrophil activation involved in immune response
regulation of acute inflammatory response

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

granulocyte activation [inference]

neutrophil activation [inference]

neutrophil activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

granulocyte activation [inference]

neutrophil activation [inference]

neutrophil activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

granulocyte activation [inference]

neutrophil activation [inference]

neutrophil activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

neutrophil activation involved in immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

regulation of neutrophil mediated cytotoxicity

regulation of myeloid leukocyte mediated immunity [inference]

regulation of neutrophil mediated cytotoxicity

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

regulation of neutrophil mediated cytotoxicity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
zymogen granule
extracellular region
nuclear envelope
nucleus	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

zymogen granule

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

zymogen granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

zymogen granule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
actin binding
DNA binding
deoxyribonuclease activity	IEA	22301074
DNA nuclease activity	IEA	22301074
deoxyribonuclease I activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

deoxyribonuclease activity

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

deoxyribonuclease activity

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Deoxyribonuclease I

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
DNA catabolic process
catalytic activity
deoxyribonuclease I activity
hydrolase activity
nuclease activity

Displaying **all 3** entries
InterPro
Deoxyribonuclease I
Endonuclease/exonuclease/phosphatase superfamily
Endonuclease/exonuclease/phosphatase

Ortholog

Displaying entries **1 - 10** of 93 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1773	HUMAN26232
Mus musculus	13419	MOUSE18845
Rattus norvegicus	25633	RATNO00684
Bos taurus	282217	BOVIN20185
Sus scrofa	397051	PIGXX21020
Canis lupus familiaris	403413	CANLF16626
Danio rerio	436947	DANRE30870
Pan troglodytes	453867	PANTR11610
Macaca mulatta	704119	MACMU27209
Monodelphis domestica	100013962	MONDO30447