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poly(ADP-ribose) polymerase 2

Summary

Gene Symbol

PARP2

Aliases

ARTD2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10038

HGNC

272

PubChem

10038

Alliance of Genome Resources

HGNC:272

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
Allosteric enzyme
Alternative splicing
Chromosome
DNA repair
DNA-binding
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UGN5	ADP-ribosyltransferase diphtheria toxin-like 2 DNA ADP-ribosyltransferase PARP2 NAD(+) ADP-ribosyltransferase 2 Poly[ADP-ribose] synthase 2 Protein poly-ADP-ribosyltransferase PARP2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
positive regulation of cell growth involved in cardiac muscle cell development	IEA
decidualization	ISS
base-excision repair	IEA
cellular response to DNA damage stimulus	IDA	34108479
DNA repair	IDA	30104678 34108479

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

macromolecule modification [inference]

DNA modification [inference]

DNA ADP-ribosylation

protein modification process [inference]

post-translational protein modification [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

hippocampal neuron apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

DNA repair-dependent chromatin remodeling

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to oxygen-glucose deprivation

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to oxygen-glucose deprivation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IDA	26704974
site of DNA damage	IDA	26704974 30104678 32939087 34108479
nucleolus	IBA IDA	15615785
nucleoplasm	IDA	15615785

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

site of DNA damage

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
poly-ADP-D-ribose modification-dependent protein binding	IDA	30104678
chromatin binding	IDA	32939087
NAD+-protein ADP-ribosyltransferase activity	IBA IDA	25043379 28190768 32028527 32939087 34732825 34795260
NAD+-protein-serine ADP-ribosyltransferase activity	IDA	28190768 32028527 32939087 34108479 34732825 34795260
nucleosome binding	IDA	32939087

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+-protein ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding

modification-dependent protein binding [inference]

ADP-D-ribose modification-dependent protein binding [inference]

poly-ADP-D-ribose modification-dependent protein binding

protein-containing complex binding [inference]

chromatin binding

nucleosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

carbohydrate derivative binding [inference]

poly-ADP-D-ribose binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000129484

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying entries **11 - 20** of 39 in total

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DO ID	Disease Name	Source
DOID:14227	azoospermia	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1791	peritoneal carcinoma	DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET
DOID:1936	atherosclerosis	DisGeNET
DOID:2237	hepatitis	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET
DOID:2893	cervix carcinoma	DisGeNET DisGeNET
DOID:3192	neurilemmoma	DisGeNET

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	3565967	WB:WBGene00004050
Danio rerio	100007906	ZFIN:ZDB-GENE-031113-6	DANRE28225
Astyanax mexicanus	103030103		ASTMX21235
Ictalurus punctatus	108267508		ICTPU32437
Electrophorus electricus	113584153		ELEEL33390
Salmo trutta	115157293		SALTR61143
Gadus morhua	115549290		GADMO56917
Sparus aurata	115572982		SPAAU37008
Xenopus laevis	446370	Xenbase:XB-GENE-1001705
Xenopus laevis	108715186	Xenbase:XB-GENE-17343778

GlyTouCan

GlyComb

GlycoPOST

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Acknowledgements