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cytochrome P450, family 3, subfamily A, polypeptide 4

Summary

Gene Symbol

CYP3A4

Organism

Callithrix jacchus (white-tufted-ear marmoset)

External Links

NCBI Gene: 100404344
KEGG Gene ID: cjc:100404344
PubChem: 100404344

Annotation

Keyword

Heme
Membrane
Microsome
Monooxygenase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O18993	CYPIIIA21 Cytochrome P450 CM3A-10

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
steroid metabolic process	IEA	30032202
oxidative demethylation	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
iron ion binding	IEA	22301074
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	22301074
heme binding	IEA	22301074
estrogen 16-alpha-hydroxylase activity	IEA	30032202
testosterone 6-beta-hydroxylase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K17689

Name

cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]

References

Rhea

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Ortholog

Displaying entries **31 - 40** of **125** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ornithorhynchus anatinus	100091970		ORNAN15553
Sarcophilus harrisii	100918011		SARHA12041
Erinaceus europaeus	103125505		ERIEU10284
Erinaceus europaeus	103127369		ERIEU10284
Erinaceus europaeus	103127370		ERIEU10284
Erinaceus europaeus	132533132		ERIEU10284
Cercocebus atys	105584398		CERAT37304
Cercocebus atys	105584402		CERAT37304
Macaca fascicularis	102144258		MACFA28905
Macaca mulatta	678670		MACMU32289

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: August 19, 2024