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ADAM metallopeptidase with thrombospondin type 1 motif 5

Summary

Gene Symbol

ADAMTS5

Organism

Callithrix jacchus (white-tufted-ear marmoset)

External Links

NCBI Gene: 100407772
PubChem: 100407772

Annotation

Keyword

Calcium
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
F6VXD6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
endocardial cushion morphogenesis
pulmonary valve morphogenesis
extracellular matrix organization	IEA	22301074 30032202
defense response to bacterium

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

tissue morphogenesis [inference]

mesenchyme morphogenesis [inference]

endocardial cushion morphogenesis

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	IEA	22301074
extracellular space

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA	22301074
heparin binding
extracellular matrix binding
metalloendopeptidase activity	IEA	22301074 30032202
identical protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

I: Lipid transport and metabolism
K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 6** entries
InterPro
ADAM, cysteine-rich domain
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **41 - 50** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Neolamprologus brichardi	102779690			NEOBR25294
Astyanax mexicanus	103046017			ASTMX18890
Poecilia formosa	103147102			POEFO13444
Chlorocebus sabaeus	103217657			CHLSB08045
Carlito syrichta	103263052	1868482_0:0029f8		CARSF08322
Cynoglossus semilaevis	103389702			CYNSE07959
Poecilia reticulata	103475784			POERE21434
Nannospalax galili	103752354			NANGA18886
Rhinopithecus roxellana	104678208	61622_0:003505		RHIRO17576
Esox lucius	105030501			ESOLU65020

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024