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ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Summary

Gene Symbol

St3gal1

Organism

Heterocephalus glaber (naked mole-rat)

External Links

NCBI Gene: 101720225
KEGG Gene ID: hgl:101720225
PubChem: 101720225

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
G5C6Q9	Gal-NAc6S Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase Monosialoganglioside sialyltransferase ST3Gal I ST3GalA.1 ST3O Sialyltransferase 4A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
protein glycosylation	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

Displaying 1 entry
GO Term	Evidence Code	PMID
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity [inference]

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

KEGG BRITE Database

Orthology

K00780

Name

beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.3.2 2.4.3.4]

References

1383214

Reactions

Displaying **all 5** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05949	2.4.3.2	G37184KW	G40183QN
R05942	2.4.3.2	G48558GR	G46677TE
R05957	2.4.3.2	G21856LC	G03277YI
R05967	2.4.3.2	G99053DY	G32254QI
R05913	2.4.3.4	G00031MO	G65562ZE

Rhea

RHEA:52380

a β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.2

PMID

RHEA:18021

CMP-N-acetyl-β-neuraminate + a ganglioside GM1 (d18:1(4E))

H⁺ + CMP + a ganglioside GD1a (d18:1(4E))

Enzyme

2.4.3.2

PMID

RHEA:21616

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.4

PMID

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	6482		HUMAN95613
Mus musculus	20442	10090_1:004777	MOUSE15580
Bos taurus	282351		BOVIN05685
Rattus norvegicus	362924	10116_1:002b52
Sus scrofa	445537		PIGXX22827
Pan troglodytes	450114		PANTR43310
Canis lupus familiaris	482050		CANLF03231
Macaca mulatta	698004		MACMU44267
Monodelphis domestica	100032599		MONDO18815
Equus caballus	100069007		HORSE42812

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements