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nucleophosmin/nucleoplasmin 2

Summary

Gene Symbol

NPM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10361

PubChem

10361

Alliance of Genome Resources

HGNC:7930

Annotation

Keyword

3D-structure
Alternative splicing
Chaperone
Chromatin regulator
Developmental protein
Fertilization
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86SE8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
blastocyst development	IMP	12714744
chromatin remodeling	IDA	12714744
chromatin remodeling	IBA
regulation of exit from mitosis	IMP	12714744
single fertilization	IMP	12714744

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

oocyte differentiation

cellular developmental process [inference]

cell differentiation [inference]

oocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte differentiation

fertilization [inference]

single fertilization

cellular process involved in reproduction in multicellular organism [inference]

oocyte differentiation

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte differentiation

anatomical structure development [inference]

blastocyst development

cellular developmental process [inference]

cell differentiation [inference]

oocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of meiotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of meiotic nuclear division

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of meiotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of meiotic nuclear division

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of meiotic nuclear division

regulation of nuclear division [inference]

regulation of meiotic nuclear division [inference]

positive regulation of meiotic nuclear division

positive regulation of nuclear division [inference]

positive regulation of meiotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of meiotic nuclear division

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of exit from mitosis

regulation of cell cycle process [inference]

regulation of meiotic nuclear division [inference]

positive regulation of meiotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of meiotic nuclear division

regulation of cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of exit from mitosis

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of meiotic nuclear division

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

positive regulation of meiotic nuclear division

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

positive regulation of meiotic nuclear division

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic nuclear division

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chromatin	IDA	12714744
nucleus	IDA	12714744
nucleoplasm	IBA
nucleolus	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chromatin binding	IBA
RNA binding	IBA
protein binding	IPI	25416956 26871637 28514442 31515488 32296183 33961781
enzyme binding	IEA
histone binding	TAS	12581654

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nucleoplasmin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
chromatin binding
histone binding

Displaying **all 3** entries
InterPro
Nucleoplasmin core domain superfamily
Nucleoplasmin core domain
Nucleoplasmin family

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	4869	FB:FBgn0016685
Xenopus tropicalis	10361	Xenbase:XB-GENE-999546
Drosophila melanogaster	18148	FB:FBgn0016685
Rattus norvegicus	290359		RATNO10455
Mus musculus	328440		MOUSE13100
Pan troglodytes	464038		PANTR42090
Equus caballus	100056399		HORSE29167
Ornithorhynchus anatinus	100084554		ORNAN22238
Sus scrofa	100154488		PIGXX06357
Bos taurus	100316905		BOVIN34690