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ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Summary

Gene Symbol

ST3GAL1

Organism

Cercocebus atys (sooty mangabey)

External Links

NCBI Gene: 105588352
KEGG Gene ID: caty:105588352
PubChem: 105588352

Annotation

Keyword

Glycoprotein
Golgi apparatus
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2K5L7V5	Gal-NAc6S Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase Monosialoganglioside sialyltransferase ST3Gal I ST3GalA.1 ST3O Sialyltransferase 4A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
protein glycosylation	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

Displaying 1 entry
GO Term	Evidence Code	PMID
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity [inference]

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cercopithecoidea

Group Name

CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
ganglioside biosynthetic process via lactosylceramide
memory B cell differentiation
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
sialylation
sialyltransferase activity
transferase activity

Displaying **all 3** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29
Sialyltransferase

KEGG BRITE Database

Orthology

K00780

Name

beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.3.2 2.4.3.4]

References

1383214

Reactions

Displaying **all 5** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05949	2.4.3.2	G37184KW	G40183QN
R05942	2.4.3.2	G48558GR	G46677TE
R05957	2.4.3.2	G21856LC	G03277YI
R05967	2.4.3.2	G99053DY	G32254QI
R05913	2.4.3.4	G00031MO	G65562ZE

Rhea

RHEA:52380

a β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.2

PMID

RHEA:18021

CMP-N-acetyl-β-neuraminate + a ganglioside GM1 (d18:1(4E))

H⁺ + CMP + a ganglioside GD1a (d18:1(4E))

Enzyme

2.4.3.2

PMID

RHEA:21616

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.4

PMID

Ortholog

Displaying entries **11 - 20** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100400713	CALJA13680
Pongo abelii	100438644	PONAB34876
Ailuropoda melanoleuca	100467054	AILME15985
Anolis carolinensis	100553436	ANOCA05282
Nomascus leucogenys	100583104	NOMLE11460
Loxodonta africana	100667581	LOXAF16560
Cavia porcellus	100720961	CAVPO17263
Sarcophilus harrisii	100924982	SARHA14058
Otolemur garnettii	100966471	OTOGA09370
Pan paniscus	100987531	PANPA38924

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements