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ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Summary

Gene Symbol

ST6GALNAC2

Aliases

ST6GalNAII
STHM

Organism

Homo sapiens (human)

External Links

NCBI Gene

10610

GGDB ID

gg057

HGNC

10867

mRNA

NM_006456

map

17q25.1

Protein

NP_006447

OMIM

610137

KEGG Gene ID

hsa:10610

PubChem

10610

Alliance of Genome Resources

HGNC:10867

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UJ37	GalNAc alpha-2,6-sialyltransferase II ST6GalNAc II SThM Sialyltransferase 7B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA IDA	10742600
protein sialylation	IDA	10742600
viral protein processing	TAS
O-glycan processing	TAS
protein glycosylation	IDA	29251719

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

sialylation [inference]

protein sialylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

viral process [inference]

viral protein processing

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA IDA TAS	10742600 29251719
sialyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg057

Gene Symbol

ST6GALNAC2

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00031MO	G56682BC	10742600
CMP-Neu5Ac	G65562ZE	G01614ZM	10742600

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00031MO	G56682BC	10536037 10742600
CMP-Neu5Ac	G65562ZE	G01614ZM	10536037 10742600

Displaying entries **1 - 10** of 11 in total

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Donor	Acceptor	Reference
CMP-Neu5Ac	G00031MO	10742600 11062056
CMP-Neu5Ac	G65562ZE	11062056
CMP-Neu5Ac	G46677TE	11062056
CMP-Neu5Ac	G49108TO	11062056
CMP-Neu5Ac	G64527IJ	11062056
CMP-Neu5Ac	G00055MO	10742600 11062056
CMP-Neu5Ac	G21856LC	10742600 11062056
CMP-Neu5Ac	G00056MO	10742600 11062056
CMP-Neu5Ac	G57321FI	10536037 10742600 11062056
CMP-Neu5Ac	G48558GR	11062056

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221134	XM_221134
Mus musculus	NP_033206	NM_009180

KEGG BRITE Database

Orthology

K06616

Name

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7B) [EC:2.4.3.3]

References

10742600

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05914	2.4.3.3 2.4.3.7	G65562ZE	G01614ZM
R12704	2.4.3.3	G00031MO	G28694FA

Rhea

RHEA:11136

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

a β-D-galactosyl-(1→3)-[N-acetyl-α-neuraminyl-(2→6)]-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.3

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:2848	obsolete melancholia	DisGeNET
DOID:2986	IgA glomerulonephritis	DisGeNET
DOID:1909	melanoma	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1470	major depressive disorder	DisGeNET
DOID:1595	melancholic depression	DisGeNET
DOID:1596	depressive disorder	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:3459	breast carcinoma	DisGeNET DisGeNET

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Lepisosteus oculatus	102690342		LEPOC01811
Danio rerio	407706	ZFIN:ZDB-GENE-050309-58
Danio rerio	100001225	ZFIN:ZDB-GENE-120104-5
Salmo salar	106601522		SALSA23402
Salmo trutta	115202301		SALTR26367
Gadus morhua	115561080		GADMO38238
Xenopus laevis	108701135	Xenbase:XB-GENE-17342044
Xenopus laevis	108702826	Xenbase:XB-GENE-6486210
Xenopus tropicalis	395053	Xenbase:XB-GENE-961127
Chrysemys picta bellii	101951888		CHRPI01823

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements