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tyrosyl-tRNA synthetase 1

Summary

Gene Symbol

Yars1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

107271

PubChem

107271

Alliance of Genome Resources

MGI:2147627

Annotation

Keyword

ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Cytoplasm
Nucleus
Phosphoprotein
Protein biosynthesis
Proteomics identification
Reference proteome
tRNA-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2A7S7	Tyrosyl-tRNA synthetase
Q91WQ3	Tyrosyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tyrosyl-tRNA aminoacylation	IEA ISO
response to starvation	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

response to stimulus [inference]

response to stress [inference]

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nuclear body	IEA ISO
nucleus	ISO ISS
cytosol	ISO ISS
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
tRNA binding	IEA
small molecule binding	ISO ISS
ATP binding	IEA
tyrosine-tRNA ligase activity	IBA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

tyrosine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity [inference]

tyrosine-tRNA ligase activity

binding [inference]

small molecule binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Tyrosine-tRNA ligase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis

Displaying **all 6** entries
Gene Ontology
ATP binding
ligase activity
nucleotide binding
tRNA aminoacylation for protein translation
tyrosine-tRNA ligase activity
tyrosyl-tRNA aminoacylation

Displaying **all 5** entries
InterPro
Aminoacyl-tRNA synthetase, class Ic
Nucleic acid-binding, OB-fold
Rossmann-like alpha/beta/alpha sandwich fold
Tyrosine-tRNA ligase
tRNA-binding domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110199	Charcot-Marie-Tooth disease dominant intermediate C	Alliance of Genome Resources
DOID:070355	multisystem proteinopathy	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources
DOID:870	neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **117** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	853097		SGD:S000003417
Monodelphis domestica	100025987			MONDO21615
Pongo abelii	100173008			PONAB19900
Salmo salar	100196228			SALSA96400
Taeniopygia guttata	100225661			TAEGU13801
Oryctolagus cuniculus	100353312			RABIT14242
Callithrix jacchus	100403207			CALJA42039
Ailuropoda melanoleuca	100475893			AILME10100
Anolis carolinensis	100560603			ANOCA11837
Nomascus leucogenys	100595452			NOMLE06096

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Last updated: December 9, 2024