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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
MBL associated serine protease 2
Summary
- Gene Symbol
-
- MASP2
- Aliases
-
- MAP-2
- Map19
- mannose-binding lectin associated protein 19
- mannose-binding lectin-associated serine protease 2
- sMAP
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Autocatalytic cleavage
- Calcium
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Hydroxylation
- Metal-binding
- Proteomics identification
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Proteins
| UniProt | Protein Name |
|---|---|
| O00187 |
|
| A0A8V8TQY3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| complement activation, classical pathway | ||
| complement activation, lectin pathway | ||
| proteolysis |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region |
|
|
| extracellular space | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| peptidase activity | ||
| serine-type endopeptidase activity | ||
| calcium ion binding | ||
| calcium-dependent protein binding | ||
| complement component C4b binding |
GO Hierarchy
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060192 | Crohn's colitis | |
| DOID:0060295 | complement component 2 deficiency | |
| DOID:0060297 | complement component 4a deficiency | |
| DOID:0060298 | complement component 4b deficiency | |
| DOID:0060299 | complement component 6 deficiency | |
| DOID:0060300 | complement component 7 deficiency | |
| DOID:0060301 | type I complement component 8 deficiency | |
| DOID:0060302 | type II complement component 8 deficiency | |
| DOID:0060303 | complement component 9 deficiency | |
| DOID:0060319 | cardiac arrest |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0002725 | Systemic lupus erythematosus |
| HP:0004431 | Complement deficiency |
| HP:0004431 | Reduced circulating complement concentration |
| HP:0006532 | Recurrent pneumonia |
| HP:0100279 | Ulcerative colitis |
| Disease ID | Disease Name |
|---|---|
| OMIM:613791 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 560277 | ZFIN:ZDB-GENE-060130-154 | DANRE24161 | |
| 103023364 | ASTMX04787 | ||
| 108276220 | ICTPU08117 | ||
| 113581290 | ELEEL28004 | ||
| 373654 | Xenbase:XB-GENE-1007496 | ||
| 108696362 | Xenbase:XB-GENE-17330991 | ||
| 496446 | Xenbase:XB-GENE-1007491 | ||
| 101950973 | CHRPI32749 | ||
| 109314472 | CROPO20740 | ||
| 100932261 | SARHA02490 |
