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Standards Ontologies Notations
MBL associated serine protease 2

Summary
Gene Symbol
  • MASP2
Aliases
  • MAP-2
  • Map19
  • mannose-binding lectin associated protein 19
  • mannose-binding lectin-associated serine protease 2
  • sMAP
Organism
Homo sapiens (human)
External Links
NCBI Gene
10747
HGNC
6902
KEGG Gene ID
hsa:10747
PubChem
10747
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Autocatalytic cleavage
  • Calcium
  • Complement pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Hydroxylation
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Sushi
Proteins
Displaying all 2 entries
UniProt Protein Name
O00187
  • MBL-associated serine protease 2
  • Mannose-binding protein-associated serine protease 2
A0A8V8TQY3
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
complement activation, classical pathway
complement activation, lectin pathway
proteolysis
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
KEGG BRITE Database
Orthology
K03993
Name
mannan-binding lectin serine protease 2 [EC:3.4.21.104]
References
Disease
Disease Ontology
Displaying entries 31 - 40 of 109 in total
DO ID Disease Name Source
DOID:0110748 obsolete type 1 diabetes mellitus 9
DOID:0110749 type 1 diabetes mellitus 10
DOID:0110750 type 1 diabetes mellitus 11
DOID:0110751 type 1 diabetes mellitus 12
DOID:0110752 type 1 diabetes mellitus 13
DOID:0110753 type 1 diabetes mellitus 15
DOID:0110754 type 1 diabetes mellitus 17
DOID:0110755 type 1 diabetes mellitus 18
DOID:0110756 type 1 diabetes mellitus 19
DOID:0110757 type 1 diabetes mellitus 20
The Human Phenotype Ontology
Displaying all 6 entries
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0002725 Systemic lupus erythematosus
HP:0004431 Complement deficiency
HP:0004431 Reduced circulating complement concentration
HP:0006532 Recurrent pneumonia
HP:0100279 Ulcerative colitis
Displaying 1 entry
Disease ID Disease Name
OMIM:613791
  • immunodeficiency due to MASP-2 deficiency
PubChem Disease
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
Ortholog
Displaying entries 21 - 30 of 50 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
487447 CANLF07183
100466924 AILME09207
101678006 MUSPF18612
101099568 FELCA19666
122226947 PANLE09882
100056770 HORSE28453
505819 BOVIN08299
102169785 CAPHI06802
101112586 SHEEP03726
17175 MGI:1330832 MOUSE39731
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024