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3-hydroxy-3-methylglutaryl-CoA lyase

Summary

Gene Symbol

HMGCL

Organism

Rhinopithecus bieti (black snub-nosed monkey)

External Links

NCBI Gene: 108538410
KEGG Gene ID: rbb:108538410
PubChem: 108538410

Annotation

Keyword

Acetylation
Disulfide bond
Metal-binding
Mitochondrion
Peroxisome
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2K6MH78	3-hydroxy-3-methylglutarate-CoA lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ketone body biosynthetic process	IEA	30032202
leucine catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

ketone body biosynthetic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA lyase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity [inference]

hydroxymethylglutaryl-CoA lyase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01640

Name

hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]

References

17692550

Rhea

(3S)-hydroxy-3-methylglutaryl-CoA

acetoacetate + acetyl-CoA

Enzyme

4.1.3.4

PMID

Ortholog

Displaying entries **21 - 30** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pan paniscus	100987057		PANPA00585
Pan troglodytes	456624		PANTR20240
Homo sapiens	3155		HUMAN48065
Canis lupus familiaris	100855521		CANLF07029
Ursus americanus	123782471		URSAM13236
Mustela putorius furo	101675648		MUSPF18475
Panthera leo	122226493		PANLE11131
Tursiops truncatus	101337799		TURTR14594
Balaenoptera musculus	118880352		BALMU22374
Equus caballus	100057686		HORSE27468

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Last updated: August 19, 2024