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phospholipase A and acyltransferase 3

Summary

Gene Symbol

PLAAT3

Aliases

AdPLA
H-REV107-1
HREV107
HREV107-3
MGC118754.
PLAAT-3
adipose-specific PLA2
phospholipase A/acyltransferase‐3

Organism

Homo sapiens (human)

External Links

NCBI Gene

11145

HGNC

17825

KEGG Gene ID

hsa:11145

PubChem

11145

Alliance of Genome Resources

HGNC:17825

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasm
Disease variant
Endoplasmic reticulum
Host-virus interaction
Hydrolase
Lipid degradation
Lysosome
Mitochondrion
Nucleus
Peroxisome
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P53816	Adipose-specific phospholipase A2 Group XVI phospholipase A1/A2 H-rev 107 protein homolog HRAS-like suppressor 1 HRAS-like suppressor 3 HREV107-3 Renal carcinoma antigen NY-REN-65

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	ISS
peroxisome organization	ISS
membrane disassembly	ISS
phospholipid biosynthetic process	IEA
organelle disassembly	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

N-acylphosphatidylethanolamine metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

ether lipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

lipid catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

ether lipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

small molecule metabolic process [inference]

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

lipid catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

ether lipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

N-acylphosphatidylethanolamine metabolic process

organic substance catabolic process [inference]

lipid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

phospholipid biosynthetic process

ether lipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylethanolamine acyl-chain remodeling

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lens fiber cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cellular component disassembly [inference]

membrane organization [inference]

membrane disassembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lens fiber cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of adipose tissue development

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nuclear envelope	ISS
endoplasmic reticulum	ISS
cytosol	ISS TAS
cytoplasm	IBA
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

microbody membrane [inference]

peroxisomal membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
acyltransferase activity
protein binding	IPI	16189514 17374643 25416956 32296183
1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

carboxylic ester hydrolase activity [inference]

binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000176485

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K16817

Name

HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]

References

22605381

Rhea

RHEA:18689

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 2-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.32

PMID

RHEA:15801

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

RHEA:36231

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

Disease

Disease Ontology

Displaying entries **11 - 18** of 18 in total

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DO ID	Disease Name	Source
DOID:3347	osteosarcoma	DisGeNET DisGeNET
DOID:3361	childhood osteosarcoma	DisGeNET
DOID:3376	bone osteosarcoma	DisGeNET DisGeNET
DOID:3459	breast carcinoma	DisGeNET
DOID:4440	seminoma	Alliance of Genome Resources
DOID:5672	large intestine cancer	DisGeNET
DOID:9256	colorectal cancer	DisGeNET
DOID:9261	nasopharynx carcinoma	DisGeNET

PubChem Disease

MedGen Diseases

Lipodystrophy, familial partial, type 9

OMIM Phenotypes

LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 9; FPLD9

KEGG Diseases

Familial partial lipodystrophy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006774
Gene Name: phospholipase A2, group XVI

Ortholog

Displaying entries **41 - 49** of 49 in total

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Species	Gene ID	Orthologous MAtrix
Chinchilla lanigera	102003033	CHILA07175
Aotus nancymaae	105724499	AOTNA33038
Saimiri boliviensis boliviensis	101045288	SAIBB01011
Rhinopithecus roxellana	104672811	RHIRO26204
Nomascus leucogenys	100593041	NOMLE29378
Equus asinus asinus	106833654	EQUAS30347
Pteropus vampyrus	105297827	PTEVA04415
Propithecus coquereli	105827470	PROCO12054
Nannospalax galili	103735074	NANGA24628

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements