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chitinase 1

Summary

Gene Symbol

CHIT1

Aliases

CHI3
CHIT
chitotriosidase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1118

HGNC

1936

KEGG Gene ID

hsa:1118

PubChem

1118

Alliance of Genome Resources

HGNC:1936

Annotation

Keyword

3D-structure
Alternative splicing
Chitin degradation
Chitin-binding
Direct protein sequencing
Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13231	Chitinase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chitin catabolic process	IBA IDA TAS	19725875 9748235
response to bacterium	TAS	9402970
polysaccharide catabolic process	IEA
immune response	NAS	9748235
polysaccharide digestion	TAS

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

amino sugar metabolic process [inference]

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

glucosamine-containing compound metabolic process [inference]

chitin metabolic process [inference]

chitin catabolic process

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

multicellular organismal process [inference]

digestion [inference]

polysaccharide digestion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
specific granule lumen	TAS
tertiary granule lumen	TAS
extracellular region	IBA TAS
lysosome	IEA
extracellular space	IDA	19725875

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	33961781
endochitinase activity	IDA	19725875
hydrolase activity, hydrolyzing O-glycosyl compounds	TAS
chitinase activity	IBA IDA TAS	11085997 9748235
chitin binding	IBA TAS	9748235

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

chitinase activity

endochitinase activity

binding [inference]

protein binding

carbohydrate derivative binding [inference]

chitin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Chitinase A

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
chitin binding
chitin catabolic process
chitinase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 5** entries
InterPro
Chitinase II
Chitinase insertion domain superfamily
Glycoside hydrolase family 18, catalytic domain
Glycoside hydrolase superfamily
Glycosyl hydrolases family 18 (GH18) active site

KEGG BRITE Database

Orthology

K01183

Name

chitinase [EC:3.2.1.14]

References

Disease

PubChem Disease

MedGen Diseases

Chitotriosidase deficiency

OMIM Phenotypes

CHITOTRIOSIDASE DEFICIENCY; CHITD

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 54 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Callithrix jacchus	100408723		CALJA17069
Callithrix jacchus	100409097		CALJA17069
Pongo abelii	100447861	9601_0:00074f	PONAB19515
Sus scrofa	100512552		PIGXX36519
Nomascus leucogenys	100600588		NOMLE37661
Loxodonta africana	100677069		LOXAF14400
Cricetulus griseus	100750757		CRIGR05322
Sarcophilus harrisii	100928636		SARHA06471
Otolemur garnettii	100957327		OTOGA09968
Pan paniscus	100991992	9597_0:00015e

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements