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cholinergic receptor muscarinic 1

Summary

Gene Symbol

CHRM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1128

PubChem

1128

Alliance of Genome Resources

HGNC:1950

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53XZ3
P11229

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
signal transduction	TAS	1411529
G protein-coupled receptor signaling pathway	TAS	7925360
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA
phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	9603968

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

saliva secretion

nervous system process [inference]

cognition

secretion by tissue [inference]

saliva secretion

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

saliva secretion

secretion by tissue [inference]

saliva secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of monoatomic ion transport [inference]

positive regulation of ion transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of ion transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of locomotion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of ion transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of cell population proliferation [inference]

regulation of glial cell proliferation

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

regulation of body fluid levels [inference]

body fluid secretion [inference]

saliva secretion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
membrane	TAS	7925360
dendrite	IBA
presynaptic membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	TAS	9614217
G protein-coupled serotonin receptor activity
protein binding	IPI	21056967
G protein-coupled acetylcholine receptor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050214	Lambert-Eaton myasthenic syndrome	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:437	myasthenia gravis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Pan paniscus	100970743	PANPA06937
Papio anubis	101002299	PAPAN05928
Felis catus	101093801	FELCA23759
Octodon degus	101589927	OCTDE25301
Jaculus jaculus	101593694	JACJA07865
Mustela putorius furo	101681312	MUSPF05803
Chrysemys picta bellii	101933014	CHRPI08946
Ictidomys tridecemlineatus	101959071	ICTTR05462
Chinchilla lanigera	102004442	CHILA25044
Capra hircus	102187843	CAPHI19390