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carbohydrate sulfotransferase 14

Summary

Gene Symbol

CHST14

Aliases

D4ST-1
HD4ST

Organism

Homo sapiens (human)

External Links

NCBI Gene

113189

GGDB ID

gg040

HGNC

24464

mRNA

NM_130468

map

15q15.1

Protein

NP_569735

OMIM

608429

KEGG Gene ID

hsa:113189

PubChem

113189

Alliance of Genome Resources

HGNC:24464

Annotation

Keyword

Carbohydrate metabolism
Disease variant
Ehlers-Danlos syndrome
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NCH0	Dermatan 4-sulfotransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dermatan sulfate proteoglycan metabolic process	IBA IDA	11470797
dermatan sulfate biosynthetic process	IDA TAS	11470797
carbohydrate biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

amino disaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	NAS	11470797
extracellular exosome	HDA	19199708
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphate ion binding	NAS	11470797
N-acetylgalactosamine 4-O-sulfotransferase activity	IDA TAS	11470797
sulfotransferase activity	IBA
protein binding	IPI	35156780

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

N-acetylgalactosamine 4-O-sulfotransferase activity

binding [inference]

protein binding

ion binding [inference]

anion binding [inference]

phosphate ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000169105

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg040

Gene Symbol

CHST14

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
PAPS	G71793UG		12080076

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
PAPS	G10271ZL		11470797
PAPS	G71793UG		11470797

Orthologous Gene

Displaying 1 entry
Species	Protein	mRNA
Mus musculus	NP_082393	NM_028117

KEGG BRITE Database

Orthology

K08105

Name

dermatan 4-sulfotransferase 1 [EC:2.8.2.35]

References

11470797

Rhea

RHEA:48052

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

2.8.2.35

PMID

Disease

Disease Ontology

Displaying entries **11 - 20** of 53 in total

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DO ID	Disease Name	Source
DOID:0110109	atrial heart septal defect 4	DisGeNET
DOID:0110110	atrial heart septal defect 5	DisGeNET
DOID:0110111	atrial heart septal defect 6	DisGeNET
DOID:0110112	atrial heart septal defect 7	DisGeNET
DOID:0110113	atrial heart septal defect 8	DisGeNET
DOID:0110114	atrial heart septal defect 9	DisGeNET
DOID:0110213	isolated cleft palate	DisGeNET
DOID:10003	sensorineural hearing loss	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of **103** in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000009	Functional abnormality of the bladder
HP:0000023	Inguinal hernia
HP:0000028	Cryptorchidism
HP:0000085	Horseshoe kidney
HP:0000100	Nephrotic syndrome
HP:0000126	Hydronephrosis
HP:0000153	Abnormality of the mouth
HP:0000160	Narrow mouth
HP:0000175	Cleft palate

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:2953	Ehlers-Danlos syndrome, musculocontractural type
OMIM:601776	Ehlers-Danlos syndrome, musculocontractural type 1

PubChem Disease

MedGen Diseases

Ehlers-Danlos syndrome, musculocontractural type 1

OMIM Phenotypes

EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE, 1; EDSMC1

KEGG Diseases

Ehlers-Danlos syndrome musculocontractural type

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103178176		CALMI14922
Latimeria chalumnae	102352110		LATCH00539
Danio rerio	404732	ZFIN:ZDB-GENE-040401-3	DANRE18944
Astyanax mexicanus	103039455		ASTMX12476
Ictalurus punctatus	108257907		ICTPU20173
Electrophorus electricus	113586374		ELEEL36907
Salmo salar	106584126		SALSA85074
Salmo trutta	115192377		SALTR28250
Sparus aurata	115591852		SPAAU67179
Xenopus laevis	108699261	Xenbase:XB-GENE-17345486

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements