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monoglyceride lipase

Summary

Gene Symbol

MGLL

Aliases

HU-K5
MAGL
MGL
monoacylglycerol lipase

Organism

Homo sapiens (human)

External Links

NCBI Gene

11343

HGNC

17038

KEGG Gene ID

hsa:11343

PubChem

11343

Alliance of Genome Resources

HGNC:17038

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Fatty acid biosynthesis
Lipid degradation
Membrane
Nitration
Phosphoprotein
Proteomics identification
Reference proteome
Serine esterase

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B2ZGL7
Q99685	HU-K5 Lysophospholipase homolog Lysophospholipase-like Monoacylglycerol lipase
A0A0C4DFN3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
regulation of endocannabinoid signaling pathway	ISS
regulation of sensory perception of pain	ISS
triglyceride catabolic process	IEA
monoacylglycerol catabolic process	ISS
acylglycerol catabolic process	IDA ISS	22969151

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of endocannabinoid signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of endocannabinoid signaling pathway

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of endocannabinoid signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

regulation of sensory perception [inference]

regulation of sensory perception of pain

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	ISS
endoplasmic reticulum membrane
plasma membrane
membrane	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein homodimerization activity	IPI	19957260
lysophospholipase activity		9495531
protein binding	IPI	28298427
acylglycerol lipase activity	IBA IDA ISS TAS	22969151

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

lysophospholipase activity

acylglycerol lipase activity

carboxylic ester hydrolase activity [inference]

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000074416

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying entries **1 - 10** of **153** in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050635	alternating hemiplegia of childhood	DisGeNET
DOID:0050741	alcohol dependence	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060215	Balo concentric sclerosis	DisGeNET
DOID:0060319	cardiac arrest	DisGeNET
DOID:0060643	primary sclerosing cholangitis	DisGeNET DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002645
Gene Name: monoglyceride lipase

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103176666		CALMI11144
Latimeria chalumnae	102351047		LATCH16016
Danio rerio	378960	ZFIN:ZDB-GENE-031006-9	DANRE42876
Ictalurus punctatus	108265630		ICTPU30119
Electrophorus electricus	113575859		ELEEL16339
Salmo salar	106566779		SALSA65373
Salmo trutta	115166239		SALTR87891
Salmo trutta	115168305		SALTR75693
Oryzias latipes	101169855		ORYLA15535
Sparus aurata	115584745		SPAAU53452

GlyTouCan

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GlycoPOST

UniCarb-DR

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Tools

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Summary

External Links

Annotation

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements