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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
cholinergic receptor nicotinic alpha 4 subunit
Summary
- Gene Symbol
-
- CHRNA4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disease variant
- Disulfide bond
- Epilepsy
- Glycoprotein
- Ion channel
- Ligand-gated ion channel
- Palmitate
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of membrane potential | ||
| behavioral response to nicotine | ||
| membrane depolarization | ||
| signal transduction | ||
| calcium ion transport |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| neuron projection | ||
| acetylcholine-gated channel complex | ||
| dendrite | ||
| synapse |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ligand-gated monoatomic ion channel activity | ||
| acetylcholine receptor activity | ||
| acetylcholine-gated monoatomic cation-selective channel activity | ||
| acetylcholine binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- AcetylCholine Receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0060682 | autosomal dominant nocturnal frontal lobe epilepsy 1 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:12217 | Lewy body dementia | |
| DOID:1574 | alcohol use disorder | |
| DOID:3635 | congenital myasthenic syndrome | |
| DOID:6000 | congestive heart failure |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 11438 | MGI:87888 | MOUSE31966 | ||
| 25590 | RGD:2346 | RATNO28590 | ||
| 31767 | FB:FBgn0015519 | |||
| 40521 | FB:FBgn0266347 | |||
| 42919 | FB:FBgn0000039 | |||
| 42920 | FB:FBgn0004118 | |||
| 172105 | WB:WBGene00006774 | |||
| 172150 | WB:WBGene00006797 | |||
| 172703 | WB:WBGene00006765 | |||
| 469999 | 9598_0:0051e1 | PANTR25339 |
