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Submissions

cholinergic receptor nicotinic beta 2 subunit

Summary

Gene Symbol

CHRNB2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1141

PubChem

1141

Alliance of Genome Resources

HGNC:1962

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P17787
Q5SXY3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 44 in total

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GO Term	Evidence Code	PMID
vestibulocochlear nerve development	ISS
acetylcholine receptor signaling pathway	IBA ISS
sensory perception of sound	ISS
regulation of dopamine metabolic process	ISS
regulation of synaptic transmission, dopaminergic	ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, cholinergic

neuromuscular synaptic transmission [inference]

synaptic transmission involved in micturition

signal transduction

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

nervous system process

sensory perception [inference]

sensory perception of pain

sensory perception of light stimulus [inference]

visual perception

sensory perception of mechanical stimulus [inference]

sensory perception of sound

cognition

learning or memory [inference]

learning

associative learning

visual learning

memory

behavior [inference]

learning or memory [inference]

learning

associative learning

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

adult behavior [inference]

behavioral response to nicotine

social behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cranial nerve morphogenesis [inference]

optic nerve morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis

anatomical structure development [inference]

nerve development [inference]

cranial nerve development [inference]

vestibulocochlear nerve development

neural nucleus development [inference]

lateral geniculate nucleus development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to acetylcholine

response to organic cyclic compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

response to nicotine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to acetylcholine

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

response to acetylcholine

response to salt [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

organic substance transport [inference]

calcium ion transport

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, dopaminergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, cholinergic

neuromuscular synaptic transmission [inference]

synaptic transmission involved in micturition

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of circadian rhythm [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep [inference]

regulation of circadian sleep/wake cycle, REM sleep

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

negative regulation of biological process [inference]

negative regulation of action potential

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendrite morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of cellular process [inference]

signal transduction

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, dopaminergic

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep [inference]

regulation of circadian sleep/wake cycle, REM sleep

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of B cell proliferation

positive regulation of B cell activation [inference]

positive regulation of B cell proliferation

regulation of action potential [inference]

negative regulation of action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane depolarization

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of action potential [inference]

negative regulation of action potential

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GO Term	Evidence Code	PMID
external side of plasma membrane	ISS
membrane	NAS	8906617
plasma membrane raft	ISS
postsynaptic specialization membrane	IEA
plasma membrane	IBA TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

acetylcholine-gated channel complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

acetylcholine-gated channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

acetylcholine-gated channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

acetylcholine-gated channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

plasma membrane raft

synaptic membrane [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

cell junction [inference]

synapse

cholinergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	27344019 29720657 33961781 8663494
ligand-gated monoatomic ion channel activity	TAS	20438829
acetylcholine receptor activity	IBA IDA	8906617
acetylcholine-gated monoatomic cation-selective channel activity	IBA IDA ISS TAS	18387948 20438829 8906617
protein-containing complex binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

acetylcholine binding

protein-containing complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

acetylcholine receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

AcetylCholine Receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 5** entries
Gene Ontology
excitatory postsynaptic potential
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Nicotinic acetylcholine receptor

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060681	autosomal dominant nocturnal frontal lobe epilepsy	Alliance of Genome Resources
DOID:0060684	autosomal dominant nocturnal frontal lobe epilepsy 3	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:3635	congenital myasthenic syndrome	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11444	MGI:87891	MOUSE38981
Drosophila melanogaster	31767	FB:FBgn0015519
Drosophila melanogaster	40521	FB:FBgn0266347
Drosophila melanogaster	42918	FB:FBgn0000036
Drosophila melanogaster	42920	FB:FBgn0004118
Rattus norvegicus	54239	RGD:2350	RATNO23427
Caenorhabditis elegans	172105	WB:WBGene00006774
Caenorhabditis elegans	172150	WB:WBGene00006797
Takifugu rubripes	446088		TAKRU46783
Canis lupus familiaris	490443		CANLF17457

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements