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poly (ADP-ribose) polymerase family, member 2

Summary

Gene Symbol

Parp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11546

PubChem

11546

Alliance of Genome Resources

MGI:1341112

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
Allosteric enzyme
Chromosome
DNA repair
DNA-binding
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O88554	ADP-ribosyltransferase diphtheria toxin-like 2 DNA ADP-ribosyltransferase PARP2 NAD(+) ADP-ribosyltransferase 2 Poly[ADP-ribose] synthase 2 Protein poly-ADP-ribosyltransferase PARP2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein auto-ADP-ribosylation	ISO ISS
DNA repair-dependent chromatin remodeling	ISO ISS
hippocampal neuron apoptotic process	IEA ISO
response to oxygen-glucose deprivation	IEA ISO
base-excision repair	IMP	11948190

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

macromolecule modification [inference]

DNA modification [inference]

DNA ADP-ribosylation

protein modification process [inference]

post-translational protein modification [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

hippocampal neuron apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

DNA repair-dependent chromatin remodeling

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to oxygen-glucose deprivation

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to oxygen-glucose deprivation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA ISO	15615785
site of DNA damage	ISO ISS
nucleus	IDA ISO	12065591
nucleolus	IBA IDA ISO	15615785

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

site of DNA damage

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
NAD+-protein-serine ADP-ribosyltransferase activity	ISO ISS
NAD+ ADP-ribosyltransferase activity	IBA IDA ISO	10364231 12065591
poly-ADP-D-ribose binding	IEA ISO
NAD+- protein-aspartate ADP-ribosyltransferase activity	ISO ISS
poly-ADP-D-ribose modification-dependent protein binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+-protein ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding

modification-dependent protein binding [inference]

ADP-D-ribose modification-dependent protein binding [inference]

poly-ADP-D-ribose modification-dependent protein binding

protein-containing complex binding [inference]

chromatin binding

nucleosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

carbohydrate derivative binding [inference]

poly-ADP-D-ribose binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

poly

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
DNA repair
NAD+ ADP-ribosyltransferase activity
NAD+-protein ADP-ribosyltransferase activity
double-strand break repair
nucleotidyltransferase activity
transferase activity

Displaying **all 4** entries
InterPro
Poly(ADP-ribose) polymerase, regulatory domain superfamily
Poly(ADP-ribose) polymerase, regulatory domain
WGR domain superfamily
WGR domain

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10038		HGNC:272	HUMAN17857
Rattus norvegicus	290027	10116_1:0046d4	RGD:1310568	RATNO09330
Pan troglodytes	465197			PANTR08190
Canis lupus familiaris	475392			CANLF04137
Macaca mulatta	701955			MACMU40305
Caenorhabditis elegans	3565967		WB:WBGene00004050
Danio rerio	100007906		ZFIN:ZDB-GENE-031113-6	DANRE28225
Monodelphis domestica	100029480			MONDO03191
Equus caballus	100072572			HORSE17821
Oryctolagus cuniculus	100351185			RABIT06273

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OrthoDB (Group)

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Acknowledgements