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glutathione S-transferase omega 2

Summary

Gene Symbol

GSTO2

Organism

Homo sapiens (human)

External Links

NCBI Gene

119391

PubChem

119391

Alliance of Genome Resources

HGNC:23064

Annotation

Keyword

3D-structure
Alternative splicing
Oxidoreductase
Reference proteome
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H4Y5	Glutathione S-transferase omega 2-2 Glutathione-dependent dehydroascorbate reductase Monomethylarsonic acid reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
L-ascorbic acid metabolic process	IBA IDA	15970797
cellular oxidant detoxification	IEA
xenobiotic metabolic process	IDA	15970797
glutathione metabolic process	IBA
cellular response to arsenic-containing substance	IDA	15970797

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

xenobiotic metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

glutathione metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

xenobiotic metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to arsenic-containing substance

cellular detoxification [inference]

cellular oxidant detoxification

response to stimulus [inference]

response to chemical [inference]

response to arsenic-containing substance [inference]

cellular response to arsenic-containing substance

cellular response to chemical stimulus [inference]

cellular response to arsenic-containing substance

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to arsenic-containing substance

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytoplasm	IBA
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 31515488 32296183
oxidoreductase activity	IDA	15970797
methylarsonate reductase activity	IEA
glutathione dehydrogenase (ascorbate) activity	IBA IDA	15970797
identical protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

glutathione disulfide oxidoreductase activity [inference]

glutathione dehydrogenase (ascorbate) activity

oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [inference]

glutathione dehydrogenase (ascorbate) activity

oxidoreductase activity, acting on phosphorus or arsenic in donors [inference]

oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor [inference]

methylarsonate reductase activity

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

glutathione transferase activity

binding [inference]

protein binding

identical protein binding

antioxidant activity [inference]

glutathione dehydrogenase (ascorbate) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glutathione

Functional Category

C: Energy production and conversion
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
glutathione metabolic process
glutathione transferase activity

Displaying **all 4** entries
InterPro
Glutathione S-transferase, C-terminal domain superfamily
Glutathione S-transferase, C-terminal-like
Glutathione S-transferase, N-terminal
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38972	FB:FBgn0035904
Drosophila melanogaster	38973	FB:FBgn0086348
Drosophila melanogaster	38974	FB:FBgn0035906
Drosophila melanogaster	38975	FB:FBgn0035907
Mus musculus	68214	MGI:1915464	MOUSE26672
Caenorhabditis elegans	175196	WB:WBGene00019636
Caenorhabditis elegans	183000	WB:WBGene00016204
Caenorhabditis elegans	184405	WB:WBGene00001792
Rattus norvegicus	309465	RGD:1310764	RATNO18844
Caenorhabditis elegans	353420	WB:WBGene00015337

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements