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C-C motif chemokine receptor 5

Summary

Gene Symbol

CCR5

Organism

Homo sapiens (human)

External Links

NCBI Gene

1234

PubChem

1234

Alliance of Genome Resources

HGNC:1606

Annotation

Keyword

3D-structure
Cell membrane
Diabetes mellitus
Disulfide bond
G-protein coupled receptor
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Palmitate
Phosphoprotein
Reference proteome
Sulfation
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P51681	CHEMR13 HIV-1 fusion coreceptor
Q38L21

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
chemotaxis	TAS	10741397
response to cholesterol	IMP	19523456
MAPK cascade	IEP	12032188
calcium-mediated signaling	IBA IDA	10679098 19523456
cell surface receptor signaling pathway	TAS	8639485

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell death [inference]

programmed cell death [inference]

apoptotic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

cell chemotaxis

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

locomotion [inference]

taxis [inference]

chemotaxis

cell chemotaxis

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to stress [inference]

defense response [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to organic cyclic compound [inference]

response to sterol [inference]

response to cholesterol

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to sterol [inference]

response to cholesterol

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

response to alcohol [inference]

response to cholesterol

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to sterol [inference]

response to cholesterol

response to alcohol [inference]

response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

sarcoplasmic reticulum calcium ion transport [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

organic substance transport [inference]

calcium ion transport

sarcoplasmic reticulum calcium ion transport [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

signaling

cell-cell signaling

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of leukocyte apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 5** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA IDA	10383387 10679098 11278962 19523456
plasma membrane	TAS
endosome	IDA	10679098
cell surface	IDA	10521508 29739880
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10816381 12421915 15001559 15660419 18230715 18632580 23235831 23480650 23597562 24405750 28381538 30542158 32296183
actin binding	IDA	12421915
coreceptor activity	TAS	10469138
chemokine receptor activity	TAS	10201901
identical protein binding	IPI	18230715 18632580 23121557

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

chemokine (C-C motif) ligand 5 binding

identical protein binding

exogenous protein binding [inference]

virus receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-C chemokine receptor type 3

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
C-C chemokine receptor activity
calcium-mediated signaling
cell chemotaxis
chemokine (C-C motif) ligand 5 binding
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
inflammatory response
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **1 - 10** of 53 in total

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DO ID	Disease Name	Source
DOID:0080599	Coronavirus infectious disease	Alliance of Genome Resources
DOID:0110759	type 1 diabetes mellitus 22	Alliance of Genome Resources
DOID:10140	dry eye syndrome	Alliance of Genome Resources
DOID:10322	berylliosis	Alliance of Genome Resources
DOID:106	pleural tuberculosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:1210	optic neuritis	Alliance of Genome Resources
DOID:12132	granulomatosis with polyangiitis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12774		MGI:107182	MOUSE64342
Rattus norvegicus	117029		RGD:620596	RATNO42203
Caenorhabditis elegans	188226		WB:WBGene00011578
Sus scrofa	414371			PIGXX03921
Pan troglodytes	450128	9598_0:001082		PANTR30964
Canis lupus familiaris	484789			CANLF07576
Felis catus	493769			FELCA04470
Bos taurus	497017			BOVIN17982
Macaca mulatta	735311			MACMU28253
Danio rerio	792495		ZFIN:ZDB-GENE-070302-1

GlyTouCan

GlyComb

GlycoPOST

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LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements