granulomatosis with polyangiitis

Summary
Synonym
  • Necrotizing respiratory granulomatosis
  • Wegener granulomatosis, formerly
Definition
An autoimmune disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.
Super Class
autoimmune disease of blood kidney disease lung disease skin disease
Disease Ontology
DOID:12132
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
Related Genes
Displaying all 5 entries
Gene ID Gene Symbol Description Source
1234 CCR5 C-C motif chemokine receptor 5
1493 CTLA4 cytotoxic T-lymphocyte associated protein 4
2204 FCAR Fc alpha receptor
3586 IL10 interleukin 10
7448 VTN vitronectin

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025