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carboxypeptidase E

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12876

PubChem

12876

Alliance of Genome Resources

MGI:101932

Annotation

Keyword

Carboxypeptidase
Cleavage on pair of basic residues
Cytoplasmic vesicle
Direct protein sequencing
Disease variant
Glycoprotein
Membrane
Metal-binding
Metalloprotease
Reference proteome
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q00493	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase
Q543R4	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cardiac left ventricle morphogenesis	ISO
cardiac left ventricle morphogenesis	IEA
proteolysis
peptide metabolic process	ISO
peptide metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac left ventricle morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

organic substance transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

nitrogen compound transport [inference]

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of branching morphogenesis of a nerve

negative regulation of multicellular organismal process [inference]

negative regulation of branching morphogenesis of a nerve

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching morphogenesis of a nerve [inference]

negative regulation of branching morphogenesis of a nerve

negative regulation of developmental process [inference]

negative regulation of branching morphogenesis of a nerve

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of branching morphogenesis of a nerve

regulation of morphogenesis of a branching structure [inference]

regulation of branching morphogenesis of a nerve [inference]

negative regulation of branching morphogenesis of a nerve

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

hormone metabolic process [inference]

peptide hormone processing [inference]

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	ISO
extracellular space	IBA
extracellular space	HDA	24006456
Golgi apparatus	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

plasma membrane region [inference]

synaptic membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

dense core granule

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

dense core granule

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
carboxypeptidase activity	ISO
carboxypeptidase activity	IMP	7663508
metallocarboxypeptidase activity	IMP	9348219
metallocarboxypeptidase activity	IBA
protein binding	IPI	16219686

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

neurexin family protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carboxypeptidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
metallocarboxypeptidase activity
peptide metabolic process
proteolysis
zinc ion binding

Displaying 1 entry
InterPro
Peptidase M14, carboxypeptidase A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	365466	WB:WBGene00012073
Danio rerio	407979		DANRE16565
Ovis aries	443028		SHEEP07098
Pan troglodytes	461592		PANTR34761
Macaca mulatta	708881		MACMU37205
Monodelphis domestica	100021886		MONDO28111
Sus scrofa	100037304		PIGXX33591
Equus caballus	100061513		HORSE27536
Ciona intestinalis	100184198		CIOIN03025
Taeniopygia guttata	100221584		TAEGU23482