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cystatin C

Summary

Gene Symbol

Cst3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13010

PubChem

13010

Alliance of Genome Resources

MGI:102519

Annotation

Keyword

Disulfide bond
Reference proteome
Secreted
Signal
Thiol protease inhibitor

Proteins

Displaying 1 entry
UniProt	Protein Name
P21460	Cystatin-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of collagen catabolic process	ISO
regulation of tissue remodeling	ISO
negative regulation of proteolysis	ISO
cellular response to oxidative stress	ISO
supramolecular fiber organization	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization

response to stimulus [inference]

response to stress [inference]

defense response

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of collagen catabolic process [inference]

negative regulation of collagen catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

negative regulation of developmental process [inference]

negative regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of blood vessel remodeling [inference]

negative regulation of blood vessel remodeling

negative regulation of developmental process [inference]

negative regulation of blood vessel remodeling

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of multicellular organismal process [inference]

regulation of tissue remodeling

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of blood vessel remodeling [inference]

negative regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
axon	ISO
nuclear membrane	ISO
cytoplasm	IBA
plasma membrane	ISO
extracellular space	HDA IBA ISO	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular non-membrane-bounded organelle [inference]

contractile fiber

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase inhibitor activity	IBA IEA ISO
endopeptidase inhibitor activity	ISO
amyloid-beta binding	ISO
peptidase inhibitor activity	ISO
protease binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

identical protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 16 in total

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DO ID	Disease Name	Source
DOID:0070027	CST3-related cerebral amyloid angiopathy	Alliance of Genome Resources
DOID:0110023	age related macular degeneration 11	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10941	intracranial aneurysm	Alliance of Genome Resources
DOID:11758	iron deficiency anemia	Alliance of Genome Resources
DOID:12842	Guillain-Barre syndrome	Alliance of Genome Resources
DOID:1389	polyneuropathy	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources

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