multiple sclerosis

Summary
Synonym
  • Generalized multiple sclerosis
  • insular sclerosis
Definition
A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Super Class
autoimmune disease of central nervous system demyelinating disease
Disease Ontology
DOID:2377
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 55 in total
Gene ID Gene Symbol Description Source
2 A2M alpha-2-macroglobulin
177 AGER advanced glycosylation end-product specific receptor
182 JAG1 jagged canonical Notch ligand 1
344 APOC2 apolipoprotein C2
355 FAS Fas cell surface death receptor
356 FASLG Fas ligand
940 CD28 CD28 molecule
942 CD86 CD86 molecule
958 CD40 CD40 molecule
1234 CCR5 C-C motif chemokine receptor 5
Displaying all 2 entries
Gene ID Gene Symbol Description Source
18646 Prf1 perforin 1 (pore forming protein)
21926 Tnf tumor necrosis factor

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025